Publications

Quantifying label enrichment from two mass isotopomers increases proteome coverage for in vivo protein turnover using heavy water metabolic labeling.
Deberneh HM, Abdelrahman DR, Verma SK, Linares JJ, Murton AJ, Russell WK, Kuyumcu-Martinez MN, Miller BF, Sadygov RG.
Commun Chem. 2023 Apr 17;6(1):72. doi: 10.1038/s42004-023-00873-x.
PMID: 37069333 Free PMC article.

Alternative polyadenylation regulation in cardiac development and cardiovascular disease.
Cao J, Kuyumcu-Martinez MN.
Cardiovasc Res. 2023 Jun 13;119(6):1324-1335. doi: 10.1093/cvr/cvad014.
PMID: 36657944 Review.

Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells.
Sotcheff SL, Chen JY, Elrod N, Cao J, Jaworski E, Kuyumcu-Martinez MN, Shi PY, Routh AL.
Pathogens. 2022 Aug 18;11(8):936. doi: 10.3390/pathogens11080936.
PMID: 36015056 Free PMC article.

Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
Cooper AM, Nutter CA, Kuyumcu-Martinez MN, Wright CW.
Mol Cell Biol. 2022 May 19;42(5):e0050321. doi: 10.1128/mcb.00503-21. Epub 2022 Apr 11.
PMID: 35404107 Free PMC article.

RBFOX2 is required for establishing RNA regulatory networks essential for heart development.
Verma SK, Deshmukh V, Thatcher K, Belanger KK, Rhyner AM, Meng S, Holcomb RJ, Bressan M, Martin JF, Cooke JP, Wythe JD, Widen SG, Lincoln J, Kuyumcu-Martinez MN.
Nucleic Acids Res. 2022 Feb 28;50(4):2270-2286. doi: 10.1093/nar/gkac055.
PMID: 35137168 Free PMC article.

RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts.
Cao J, Verma SK, Jaworski E, Mohan S, Nagasawa CK, Rayavara K, Sooter A, Miller SN, Holcomb RJ, Powell MJ, Ji P, Elrod ND, Yildirim E, Wagner EJ, Popov V, Garg NJ, Routh AL, Kuyumcu-Martinez MN.
Cell Rep. 2021 Nov 2;37(5):109910. doi: 10.1016/j.celrep.2021.109910.
PMID: 34731606 Free PMC article.

Nanopore sequencing reveals full-length Tropomyosin 1 isoforms and their regulation by RNA-binding proteins during rat heart development.
Cao J, Routh AL, Kuyumcu-Martinez MN.
J Cell Mol Med. 2021 Sep;25(17):8352-8362. doi: 10.1111/jcmm.16795. Epub 2021 Jul 24.
PMID: 34302435 Free PMC article.

Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2.
Wan X, Belanger K, Widen SG, Kuyumcu-Martinez MN, Garg NJ.
Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165620. doi: 10.1016/j.bbadis.2019.165620. Epub 2019 Nov 25.
PMID: 31778749 Free PMC article.

A developmentally regulated spliced variant of PTBP1 is upregulated in type 1 diabetic hearts.
Belanger K, Nutter CA, Li J, Yu P, Kuyumcu-Martinez MN.
Biochem Biophys Res Commun. 2019 Feb 5;509(2):384-389. doi: 10.1016/j.bbrc.2018.12.150. Epub 2018 Dec 26.
PMID: 30594394 Free PMC article.

CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart.
Belanger K, Nutter CA, Li J, Tasnim S, Liu P, Yu P, Kuyumcu-Martinez MN.
Biochem Biophys Res Commun. 2018 Sep 18;503(4):3205-3211. doi: 10.1016/j.bbrc.2018.08.126. Epub 2018 Aug 27.
PMID: 30158053 Free PMC article.

Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications.
Nutter CA, Kuyumcu-Martinez MN.
Wiley Interdiscip Rev RNA. 2018 Mar;9(2):10.1002/wrna.1459. doi: 10.1002/wrna.1459. Epub 2017 Dec 27.
PMID: 29280295 Free PMC article. Review.

Developmentally regulated alternative splicing is perturbed in type 1 diabetic skeletal muscle.
Nutter CA, Jaworski E, Verma SK, Perez-Carrasco Y, Kuyumcu-Martinez MN.
Muscle Nerve. 2017 Oct;56(4):744-749. doi: 10.1002/mus.25599. Epub 2017 Apr 17.
PMID: 28164326 Free PMC article.

Rebuilding a broken heart: lessons from developmental and regenerative biology.
Kuyumcu-Martinez MN, Bressan MC.
Development. 2016 Nov 1;143(21):3866-3870. doi: 10.1242/dev.143842.
PMID: 27803055

S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure.
Koo SJ, Spratt HM, Soman KV, Stafford S, Gupta S, Petersen JR, Zago MP, Kuyumcu-Martinez MN, Brasier AR, Wiktorowicz JE, Garg NJ.
Int J Proteomics. 2016;2016:1384523. doi: 10.1155/2016/1384523. Epub 2016 Aug 18.
PMID: 27635260 Free PMC article.

Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts.
Verma SK, Deshmukh V, Nutter CA, Jaworski E, Jin W, Wadhwa L, Abata J, Ricci M, Lincoln J, Martin JF, Yeo GW, Kuyumcu-Martinez MN.
Sci Rep. 2016 Aug 3;6:30896. doi: 10.1038/srep30896.
PMID: 27485310 Free PMC article.

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.
Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN.
Cell Rep. 2016 Jun 7;15(10):2200-2213. doi: 10.1016/j.celrep.2016.05.002. Epub 2016 May 26.
PMID: 27239029 Free PMC article.

Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice.
Chattopadhyay A, Pinkaew D, Doan HQ, Jacob RB, Verma SK, Friedman H, Peterson AC, Kuyumcu-Martinez MN, McDougal OM, Fujise K.
Sci Rep. 2016 Jan 4;6:18701. doi: 10.1038/srep18701.
PMID: 26726832 Free PMC article.

Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling.
Verma SK, Deshmukh V, Liu P, Nutter CA, Espejo R, Hung ML, Wang GS, Yeo GW, Kuyumcu-Martinez MN.
J Biol Chem. 2013 Dec 6;288(49):35372-86. doi: 10.1074/jbc.M113.507426. Epub 2013 Oct 22.
PMID: 24151077 Free PMC article.