Publications
PubMed list for Manoj K. Patel
Selected Publications:
2026
Reever CM, Boscia AR, Deutsch TCJ, Patel MP, Miralles RM, Kittur S, Fleischel EJ, Buo AML, Yorek MS, Meisler MH, Farber CR, and Patel MK. Base editing rescues seizures and sudden death in a SCN8A mutation-associated developmental epileptic encephalopathy model. Journal of Clinical Investigation 136(3): e196402. 2026. PMID: 41623181
2025
Zengeler KE, Hollis A, Deutsch TCJ, Samuels JD, Ennerfelt H, Moore KA, Steacy EJ, Sabapathy V, Sharma R, Patel MK, and Lukens JR. Inflammasome signaling in astrocytes modulates hippocampal plasticity. Immunity 58(6): 1519-1535. 2025. PMID: 40318630
2024
Miralles RM, Boscia AR, Kittur S, Hanflink JC, Panchal PS, Yorek MS, Deutsch TCJ, Reever CM, Vundela SR, Wengert ER, and Patel MK. Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy. JCI Insight 9(20): e181005. 2024. PMID: 39435659
Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth. bioRxiv. 2024. PMID: 39229003
Unspooling the thread: VIP interneurons linked with autism spectrum disorder behaviors but not seizures in Dravet syndrome. Epilepsy Curr 24(1):62-64. 2024. PMID: 38327541
2023
A water nymph’s curse and the serotonergic mechanism of postictal breathing dysfunction. Epilepsy Curr 23(6):369-371. 2023. PMID: 38269340
EpiPro, a novel, synthetic, activity-regulated promoter that targets hyperactive neurons in epilepsy for gene therapy applications. Int J Mol Sci 24(19): 14467. 2023. PMID: 37833914
Waiting to inhale: Preventing fatality from seizure-induced apnea. Epilepsy Curr 23(3):185-187. 2023. PMID: 37334424
2022
Wenker IC, Boscia AR, Lewis C, Tariq A, Miralles RM, Hanflink JC, Saraf P, and Patel MK. Forebrain epileptiform activity is not required for seizure-induced apnea in a mouse model of Scn8a epilepsy. Frontiers in Neural Circuits 16: 1002013. 2022. PMID: 36160949
Thompson JA, Miralles RM, Wengert ER, Wagley PK, Yu W, Wenker IC, and Patel MK. Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy. Epilepsia Open 7(2): 280-292. 2022. PMID: 34826216
That’s a wrap: Could controlling activity-regulated myelination prevent absence seizures? Epilepsy Curr 22(6):395-397. 2022. PMID: 36426188
It takes two to tango: Channel interplay leads to paradoxical hyperexcitability in a loss-of-function epilepsy variant. Epilepsy Curr 22(1):69-71. 2022. PMID: 35233206
2021
Wengert ER, Miralles RM, Wedgwood KC, Wagley PK, Strohm SM, Panchal PS, Idrissi AM, Wenker IC, Thompson JA, Gaykema RP, and Patel MK. Somatostatin-positive interneurons contribute to seizures in SCN8A epileptic encephalopathy. Journal of Neuroscience 41 (44): 9257-9273. 2021. PMID: 34544834
Wenker IC, Teran F, Wengert ER, Wagley PK, Panchal PS, Blizzard E, Saraf P, Wagnon J, Goodkin HP, Meisler MH, Richerson G and Patel MK. Postictal death is associated with tonic phase apnea in a mouse model of SUDEP. Annals of Neurology 89(5):1023-1035. 2021. PMID: 33604927.
Wengert ER, Wenker IC, Wagner E, Wagley PK, Gaykema RP, Shin JB and Patel MK. Adrenergic mechanisms of seizure-induced sudden death in a mouse model of SCN8A encephalopathy. Frontiers in Neuroscience 15: 581048. 2021. PMID: 33762902
Peri-ictal autonomic control of cardiac function and seizure-induced death. Front Neurosci 15:795145. 2021. PMID: 35126041
Targeted Augmentation of Nuclear Gene Output (TANGO) of SCN1A rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res 1775:147743. 2021. PMID: 34843701
One size doesn’t fit all: Variant-specific effects in SCN8A encephalopathy. Epilepsy Curr 21(3):183-185. 2021. PMID: 34867099
The role of the persistent sodium current in rpilepsy. Epilepsy Curr 21(1):40-47. 2021. PMID: 33236643
2019
Wengert ER, Tronhjem CE, Wagnon JL, Johannesen KM, Petit H, Krey I, Saga AU, Panchal PS, Strohm SM, Lange J, Kamphausen SB, Rubboli G, Lemke JR, Gardella E, Patel MK, Meisler MH, Møller RS. Biallelic inherited SCN8A variants, a rare cause of SCN8A-related developmental and epileptic encephalopathy. Epilepsia. 60:2277-2285. 2019. PMID: 31625145 Co-senior author with MHM & RSM.
Wengert ER, Saga AU, Panchal PS, Barker BS, Patel MK. Prax330 reduces persistent and resurgent sodium channel currents and neuronal hyperexcitability of subiculum neurons in a mouse model of SCN8A epileptic encephalopathy. Neuropharmacology. 158. 2019. PMID: 31278928
Prominent role of forebrain excitatory neurons in SCN8A encephalopathy. Brain 142(2):362-375. 2019. PMID: 30601941
2018
Cottrell GS, Soubrane CH, Hounshell JA, Lin H, Owenson V, Rigby M, Cox PJ, Barker BS, Ottolini M, Ince S, Bauer CC, Perez-Reyes E, Patel MK, Stevens EB, Stephens GJ. CACHD1 is an α2δ-like protein that modulates CaV3 voltage-gated calcium channel activity. J Neurosci. Sep 4. 3572-15. 2018. PMID: 30181139
The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy. Epilepsia 59(6):1166-1176. 2018. PMID: 29782051
Partial loss-of-function of sodium channel SCN8A in familial isolated myoclonus. Hum Mutat. 39(7):965-969. 2018. PMID: 29726066
2017
Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM. Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight. J Clin Invest. (3):1031-1045. 2017. PMID: 28218622
Ottolini M, Barker BS, Gaykema RP, Meisler MH, Patel MK. Aberrant sodium channel currents and hyperexcitability of medial entorhinal cortex neurons in a mouse model of SCN8A encephalopathy. J Neurosci. 37: 7643-7655. 2017. PMID: 28676574
Pro-excitatory alterations in sodium channel activity facilitate subiculum neuron hyperexcitability in temporal lobe epilepsy. Neurobiol Dis. 108:183-194. 2017. PMID: 28860087
2016
Barker BS, Ottolini M, Wagnon J, Meisler MH and Patel MK. The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin. Epilepsia. (9):1458-66. 2016. PMID: 27375106
Wheeler MA, Smith CJ, Ottolini M, Barker BS, Purohit AM, Grippo RM, Gaykema RP, Spano AJ, Beenhakker MP, Kucenas S, Patel MK, Deppmann CD, Güler AD. Genetically targeted magnetic control of the nervous system. Nature Neuroscience. 19(5):756-61. 2016. PMID: 26950006
Warthen DM, Lambeth PS, Ottolini M, Shi Y, Barker BS, Gaykema RP, Newmyer BA, Joy-Gaba J, Ohmura Y, Perez-Reyes E, Güler AD, Patel MK and Scott MM. Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake. Frontiers in Behavioral Neuroscience. 10. 63. 2016. PMID: 27065827
Alexandrou A, Brown A, Chapman M, Estacion M, Turner J, Mis M, Wilbrey A, Payne L, Gutteridge A, Cox P, Doyle R, Printzenhoff D, Lin Z, Marron B, West C, Swain N, Storer I, Stupple P, Castle N, Hounshell J, Rivara M, Randall A, Dib-Hajj S, Krafte D, Waxman S, Patel MK, Butt R, Stevens EB. Subtype-selective small molecule inhibitors reveal a fundamental role for Nav1.7 in nociceptor electrogenesis, axonal conduction and presynaptic release. PLOS ONE, 11 (4). 2016. PMID: 27050761
Central mechanisms mediating thrombospondin-4-induced pain states. J Biol Chem. 291(25):13335-48. 2016. PMID: 27129212
Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy. Ann Clin Transl Neurol. 3(2):114-23. 2016. PMID: 26900580
2015
L. Wagnon, B.S. Barker, J.A Hounshell, C. Haaxma, A. Shealy, T. Moss, S. Parikh, R.D. Messer, M.K. Patel and M.H. Meisler. Pathogenic mechanism of recurrent epileptogenic mutations of sodium channel SCN8A. Annals of Clinical and Translational Neurology. 3(2):114-23. 2015. PMID: 26900580
Sodium channel blockers: a patent review (2010 – 2014). Expert Opin Ther Pat. 25(3):279-90. 2015. PMID: 25539043
2013
Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis. J Neurophysiol. 110(5):1144-57. 2013. PMID: 23741036
2012
Hargus NJ, Jennings C, Perez-Reyes E, Bertram EH, Patel MK. Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A1 receptor activation. Epilepsia 53(1):168-76. 2012. PMID: 22126400
Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry. Bioorg Med Chem Lett. 22(20):6401-4. 2012. PMID: 22981330
Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent. Bioorg Med Chem. 20(17):5269-76. 2012. PMID: 22863530
2009
- Hargus NJ, Bertram EH, Patel MK. Adenosine A1 receptors presynaptically modulate excitatory synaptic input onto subiculum neurons. Brain Res. 1280:60-8. 2009. PMID: 19450566
- Jones PJ, Merrick EC, Batts TW, Hargus NJ, Wang Y, Stables JP, Bertram EH, Brown ML, Patel MK. Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy. Journal of Pharmacology and Experimental Therapeutics; 328(1):201-12. 2009. PMID: 18952887
2007
- Jones PJ, Wang Y, Smith M, Hargus NJ, Eidam HS, White SH, Kapur J, Brown ML, Patel MK. Hydroxyamide analogues of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. Journal of Pharmacology and Experimental Therapeutics, 320: 828-836. 2007. PMID: 17090703
- Lenkowski PW, Batts TW, Smith M, Ko S-H, Jones PJ, Taylor CH, McCusker AK, Davis GC, Hartmann HA, White HS, Brown ML, Patel MK. A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile. Neuropharmacology, 52; 1044-1054. 2007. PMID: 17174360