Park Laboratory discovering ways to halt small cell lung cancer

February 25, 2022 by

“An unexpected discovery at University of Virginia Cancer Center has allowed scientists to halt the development of small-cell lung cancer in lab mice, and the surprise finding could open the door to a new treatment approach in people.

The researchers, led by UVA’s Kwon-Sik Park and John H. Bushweller, were seeking to understand the role of a mutation in the EP300 gene in the formation of small-cell lung cancer tumors. Their experiments revealed that the gene makes a protein with surprising properties that can both foster or prevent the development of small-cell lung cancer. By preventing the gene from acting as a tumor-promoter, the researchers were able to stop the cancer from forming and spreading. This held true in both cell samples and lab mice.” [Read the complete article in UVA TODAY]