The Molecular Electron Microscopy Core (MEMC) is a state-of-the-art facility dedicated to high-resolution electron cryomicroscopy and electron cryotomography. It houses four electron microscopes, : a 300 kV Titan Krios, a 200kV Glacios, a 200kV F20, and a 120kV Spirit. These microscopes are available to researchers either for direct use, or aided by MEMC personnel. They may be used for a wide range of experiments, from the characterization of nanoparticles to high-resolution structural biology projects.

Team members can provide various levels of assistance, including complete sample preparation and image collection. The MEMC can help with all your sample preparation needs, from simple staining to cryo-FIB milling. Samples can be stained, embedded, and cut by the MEMC sample preparation specialist using our EM UC7 Ultramicrotome. For cryo-EM, the MEMC maintains two plunge-freezing systems and automatic sample loaders for the Krios and Glacios. Cryo-FIB milling, guided by correlative fluorescence and SEM via the Aquilos 2, can be used to prepare ultra-thin lamella for cutting-edge cryo-electron tomography (cryo-ET). Training is available for most procedures, including microscope use.