Ophthalmology Clinical Trials

Current Clinical Trials

Diabetic Macular Edema

  • DOVETAIL Study—A Multi-center, Non-Randomized, Open-Label, Multiple Ascending Dose Stud to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7200220 in Monotherapy and in Combination with Ranibizumab Following Intravitreal Administration in Patients with Diabetic Macular Edema.

Sponsor: F. Hoffman-La Roche; Principal Investigator: Paul Yates, MD, PhD

  • RHINE Study– A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of RO6867461 in Patients with Diabetic Macular Edema.

Sponsor: Apellis Pharmaceuticals; Principal Investigator: Paul Yates, MD, PhD

 

Geographic Atrophy

  • DERBY Study—A Phase III, Multi-Center, Randomized, Double-Masked, Sham-Controlled Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy with Sham Injections in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD).

Sponsor: Apellis Pharmaceuticals; Principal Investigator: Paul Yates, MD, PhD

  • Re-CLAIM Study—A Phase 2, Randomized, Double-Masked, Placebo-Controlled Clinical Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects with Age-Related Macular Degeneration with Geographic Atrophy

Sponsor: Stealth BioTherapeutics; Principal Investigator: Yevgeniy Shildkrot, MD

 

Neovascular Age-Related Macular Degeneration

  • PANDA Study— A Multicenter, Double-Masked, Randomized, Dose-Ranging Trial to Evaluate the Efficacy and Safety of Conbercept Intravitreal Injection in Subjects with Neovascular Age-related Macular Degeneration

Sponsor: Chengdu Biotechnology; Principal Investigator: Yevgeniy Shildkrot, MD

 

Non-Arteritic Anterior Ischemic Optic Neuropathy

  • Regenera Study—A Double-Masked Clinical Study Evaluating the Efficacy and Safety of RPh201 Treatment in Participants with Previous NAION

Sponsor: Regenera Pharmaceuticals; Principal Investigator: Steven Newman, MD

 

Primary Sjögren’s Syndrome

  • TearSolutions Study— Lacripep in Dry Eye associated with Primary Sjögren’s Syndrome

Sponsor: TearSolutions, Inc.; Principal Investigator: Tara McGehee, MD

 

For additional information about the trials or to refer a patient, contact the study coordinator:

  • Ashton Leone, MPH at (434) 243-5737 or aml7q@virginia.edu