The University of Virginia’s Department of Pathology had another strong showing at the 2020 Annual Meeting of the United States and Canadian Academy of Pathology in Los Angeles, California. Thirteen original research abstracts were presented by UVA medical students, residents, fellows, and faculty. Second-year resident Dr. Megan Dibbern was awarded the International Society of Gynecological Pathology’s prestigious W. Dwayne Lawrence Award for her platform presentation “Loss of MHC Class I Expression in PD-L1-positive HPV-Associated Cervical and Vulvar Neoplasia: A Mechanism of Resistance to Checkpoint Inhibition?”, while first-year resident Dr. Lisa Friedman was awarded 1st Place in the Gynecologic Poster section for her work entitled, “Loss of MHC Class I in Endometrial Carcinoma: A Possible Mechanism of Immunotherapeutic Resistance in Some MMR-Deficient and PD-L1-Positive Tumors.” In other meeting highlights, Dr. Robin LeGallo helped lead the organization’s first annual session on Diversity & Inclusion with a talk focused on the healthcare of transgender individuals. Dr. Anne Mills delivered a talk entitled “PD-L1 immunostaining in Cervical and Vulvar Cancer” to an audience of several hundred at the meeting of the International Society of Gynecological Pathology and a three-hour SAMs/CME course on Biomarkers in Gynecologic Pathology. The most memorable part of the meeting, however, was the fun and fellowship that the UVA folks shared over Mediterranean food at the annual departmental meeting dinner.
Oral presentations:
ISGyP Companion Society Meeting, Presenter: Anne Mills
Title: PD-L1 immunostaining in Cervical and Vulvar Cancer
USCAP Focus on Diversity and Inclusion, Presenter: Robin LeGallo
Title: Healthcare of Transgender Individuals
Short Course, Presenter: Anne Mills
Title: Tests, Targets, and Treatments: Emerging Biomarkers in Gynecologic Carcinoma
Platform, Gynecologic Pathology, Presenter: Megan Dibbern
Title: Loss of MHC Class I Expression in PD-L1-positive HPV-Associated Cervical and Vulvar Neoplasia: A Mechanism of Resistance to Checkpoint Inhibition?
Poster Presentations
- Presenter: Bre Ana David
Title: Mismatch Repair Deficiency and PD-L1 Expression in Sebaceous Carcinomas and Basal Cell Carcinomas with Sebaceous Features.
- Presenter: Marge Moore
Title: The Targetable Immune Checkpoint VISTA is Highly Expressed in a Subset of Endometrial Carcinomas, Particularly Those Exhibiting Mismatch Repair Deficiency and PD-L1 Expression.
- Presenter: Jacob Curley
Title: Looking Past PD-L1: Expression of Immune Checkpoint TIM-3 and its Ligand Galectin-9 in Cervical and Vulvar Squamous Neoplasia
- Presenter: Lisa Friedman
Title: Loss of MHC Class I in Endometrial Carcinoma: A Possible Mechanism of Immunotherapeutic Resistance in Some MMR-Deficient and PD-L1-Positive Tumors.
- Presenter: Ed Stelow
Title: Low-Grade Tubulo-Acinar Sinonasal Adenocarcinoma: A specific entity with recurrent beta-catenin mutations
- Presenter: Brian Adkins
Title: Characterizing the Lymphocyte Environment in Hospital Autopsy
- Presenter: Sarah Gradecki
Title: p16 and Rb Expression and High-Risk HPV Status of 18 Sebaceous Carcinomas of the Conjunctiva and Eyelid
- Presenter: Bea Lopes
Title: Liver Metastases from Pituitary Carcinoma Mimicking Visceral Well-Differentiated Neuroendocrine Tumor
- Presenter: Elisheva Shanes
Title: IDO Expression in Uterine Smooth Muscle Tumors: Implications for Immunotherapy
- Presenter: Marge Moore
Title: HLA-1 Loss is Common in Non-Small Cell Lung Cancer and May Contribute to Failure of Immune Checkpoint Therapy
- Presenter: Brett Kurpiel
Title: MLH1-Hypermethylation and Mutation Status Among MLH1/PMS2-Deficient Endometrial Carcinomas: Results from a Universally Screened Population
- Presenter: Taylor Jenkins
Title: PD-L1 and Mismatch Repair Status in Uterine Carcinosarcomas
