Michelle Barbeau, PhD, “Systems-level characterization of the transcriptional and signaling basis of epithelial-mesenchymal transition heterogeneity in pancreatic ductal adenocarcinoma”, 2025

8/28/2025

Abstract: Epithelial-mesenchymal transition (EMT) is a developmental program aberrantly activated in pancreatic ductal adenocarcinoma (PDAC), promoting chemoresistance and metastasis. Antagonizing EMT may be an effective adjuvant therapy approach to promote…

Lydia Kitelinger, PhD, “Immunological effects of focused ultrasound as a therapy for melanoma and breast cancer”, 2025

8/28/2025

Abstract: Focused ultrasound (FUS) is a clinically relevant and attractive therapeutic, due to its non-invasive and non-ionizing nature. By employing FUS, solid malignancies can be targeted and destroyed via mechanical…

Nikit Yadav, PhD, “Synergistic activity of combining repurposed simvastatin with irinotecan chemotherapy against glioblastoma and its underlying mechanisms”, 2025

8/28/2025

Abstract: Background and Rationale: Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with a dismal prognosis (approximately 15 months) and inevitable recurrence due to resistance towards standard-of-care…

Ryan Makin, PhD, “Evaluating the role of inflammasome activation in models of pathological ocular angiogenesis”, 2025

8/28/2025

Abstract: Pathological angiogenesis in the eye remains at the center of a myriad blinding diseases, including neovascular age-related macular degeneration (nvAMD). Elucidating the mechanisms by which these invasive neovessels proliferate…

Dionne Argyle, PhD, “Sex Differences in IgG1-Mediated Inhibition of Choroidal Neovascularization”, 2025

8/28/2025

Abstract: Sex differences significantly impact diseases involving angiogenesis, such as age- related macular degeneration (AMD), which is more prevalent in females. The basis for this sexual dimorphism is unknown. Using…

Yi He, PhD, 2023

5/2/2024

Islet-On-Chip and 3D Bioscaffolds for Islet Transplantation Abstract: Rationale: Pancreatic islet transplantation is a promising cell-based therapy for replacing damaged β-cells and helping restore insulin independence in Type 1 diabetes…

Karolina Dziewulska-Cronk, PhD, 2023

5/2/2024

Mechanisms of G6PD-deficient RBC Hemolysis Mediated by Oxidizing Drugs Abstract: According to estimates by the World Health Organization, around 250 million people contract Plasmodium spp. worldwide every year. While drugs…

Marissa Gonzales Stevens, PhD, 2023

5/2/2024

Modulation of Mitochondrial Dynamics and T Cell Metabolism Abstract: Following an encounter with a pathogen or vaccination, a population of memory CD8+ T cells specific for the encountered antigen remain…

Anupam Prakash, PhD, 2023

5/2/2024

Cellular and Molecular Regulators of RBC Alloimmunization Abstract: The vast majority of RBC transfusion recipients do not generate antibodies against alloantigens expressed on the RBC surface. We therefore set out…

Wei Feng Ma, PhD, 2023

5/2/2024

Investigating Atherosclerosis and Chemotherapy-Induced Cardiomyopathy at the Single Cell Resolution Abstract: Cardiovascular diseases (CVDs) and cancer are the leading causes of death worldwide. Central to many cardiovascular diseases, including myocardial…