C3 glomerulopathy: Clinicopathologic features and predictors of outcome

Authors: Medjeral-Thomas NP, O’Shaughnessy MM, O’Regan JA, et al.

Publication: Clin J Am Soc Nephrol 9; 46-53, 2014

C3 glomerulopathy is characterized by intensely staining glomerular deposits of C3 in the absence of significant IgG deposits.  This study describes the clinicopathologic features of a large British cohort of these patients.  One-quarter of the patients had dense deposit disease (DDD) and three-quarters had C3 glomerulonephritis (C3GN). The  DDD patients were younger, had lower C3 levels and more often had crescentic GN.  The C3GN patients were older, and had more arteriolar sclerosis, and glomerular and interstitial damage.  Those patients older than 16 years, who had DDD or crescents, were more likely to progress to end stage renal disease.