Dr.’s Ling Qi and Shengyi Sun Publish New Research in Nature Cell Biology

A newly published review in Nature Cell Biology by Drs. Ling Qi and Shengyi Sun, along with postdoctoral fellow Dr. Huilun Helen Wang and collaborator Dr. Ida Biunno, provides a comprehensive overview of the SEL1L-HRD1-mediated endoplasmic reticulum-associated degradation (ERAD) pathway in mammals. This evolutionarily conserved protein quality control system is essential for maintaining ER homeostasis and regulating diverse physiological processes in a substrate-specific manner. The review highlights recent advances in the molecular machinery and functions of the SEL1L-HRD1 ERAD complex, its emerging roles in human diseases such as ERAD-associated neurodevelopmental disorders, and potential therapeutic strategies targeting this pathway.

Wang, H.H., Biunno, I., Sun, S. et al. SEL1L–HRD1-mediated ERAD in mammals. Nat Cell Biol 27, 1063–1073 (2025). https://doi.org/10.1038/s41556-025-01690-1