Neurobiology of the autonomic nervous system and the homeostatic control of breathing
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Cell signaling of protein kinases in development and disease
Modulation of aldosterone production in health and disease.
Molecular mechanisms controlling insulin signaling and fat synthesis.
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Identifying tumor selective drug targets, Understanding the genetic drivers of tumor immune evasion
Understanding the neural code underlying motivated behaviors like feeding, drinking, and social interaction, with a focus on how malfunction in associated brain areas are involved in diseases like addiction and eating disorders
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Role of endoplasmic reticulum-associated protein degradation in health and disease
Neural Circuits in Healthy and Diseased Brains
Molecular Biology of Sphingosine 1-phosphate
Atherosclerosis, Redox Biology, Cellular Metabolism & Bioenergetics
Central respiratory circuits, Mechanisms Underlying Breathing Complexity and Central hypoventilation syndrome
Biophysics, Molecular Pharmacology