Zeng J, Alvarez-Yela AC, Casarez E, Jiang Y, Wang L, Kelly BE, Ke E, Jenkins T, Atkins KA, Janes KA, Slack-Davis JK*, Zong H* (2023) Dichotomous ovarian cancer-initiating potential of Pax8+ cells revealed by a mouse genetic mosaic model. iScience, 26(5) 106742. PMC10189502
Xu B*, Kucenas S, Zong H* (2022) zMADM (zebrafish Mosaic Analysis with Double Markers) for single-cell gene knockout and dual lineage tracing. PNAS, 119(9):e2122529119. PMC8892518
Sutcliffe MD, Galvao RP, Wang L, Kim J, Rosenfeld LK, Singh S, Zong H*, Janes KA* (2021) Premalignant oligodendrocyte precursor cells stall in a heterogeneous state of replication stress prior to gliomagenesis. Cancer Research, 81(7):1868-1882. PMC8137536
Yao M., Ventura P. B., Jiang Y., Rodriguez F. J., Wang L., Perry J. S. A., Yang Y., Wahl K., Crittenden R. B., Bennett M. L., Qi L., Gong C. C., Li X. N., Barres B. A., Bender T. P., Ravichandran K. S., Janes K. A., Eberhart C. G., Zong H., Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth, 2020; Cell. 180(3) 502-520. PMID: 31983537 | PMCID: PMC7259679
Terry T. T., Cheng T., Mahjoub M., Zong H., Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development, 2020; Dev Biol. 465(2) 130-143. PMID: 32697974 | PMCID: PMC7494377
Gonzalez PP, Kim J, Galvao RP, Cruickshanks N, Abounader R, Zong H, p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression., 2018; Glia. 66(5) 999-1015. PMID: 29392777
Ledur PF, Liu C, He H, Harris AR, Minussi DC, Zhou HY, Shaffrey ME, Asthagiri A, Lopes MB, Schiff D, Lu YC, Mandell JW, Lenz G, Zong H, Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells., 2016; Neuro-oncology. 18(10) 1413-24. PMID: 27106408 | PMCID: PMC5035523
Galvao, R.P., Kasina, A., McNeill, R.S., Harbin, J.E., Foreman, O., Verhaak, R.G.W., Nishiyama, A., Miller, C.R., Zong, H. (2014) Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multi-step reactivation process. PNAS, 111(40):E4214-23
Henner A, Ventura PB, Jiang Y, Zong H. 2013 MADM-ML, a Mouse Genetic Mosaic System with Increased Clonal Efficiency. PMID: 24143253 PuBMed
Muzumdar, M.D.*, Luo, L., Zong, H.* (2007) Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). PNAS, 104:4495-4500 PubMedPMC
Zong, H., Espinosa, S., Su, H., Muzumdar, M.D., and Luo, L. (2005) Mosaic analysis with double markers in mice. Cell, 121:479-492 PubMed
Luo, L., Zong, H. (2001) Single neuron labeling and genetic manipulation. Nature Neuroscience, 4:1158-1159 PubMed
Zong, H., Kaibuchi, K., Quilliam, L.A. (2001) The “Insert region” of RhoA is essential for Rho kinase activation and cellular transformation. Molecular and Cellular Biology, 21: 5287–5298 PubMedPMC
Zong, H., Raman, N., Mickelson-Young, L.A., Atkinson, S.J., Quilliam, L.A. (1999) Loop 6 of RhoA Confers Specificity for Effector Binding, Stress Fiber Formation, and Cellular Transformation. Journal of Biological Chemistry, 274:4551-4560 PubMed
Reviews & book chapters
Ledur PF, Onzi GR, Zong H, Lenz G, Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?, 2017; Oncotarget. 8(40) 69185-69197. PMID: 28978189 | PMCID: PMC5620329
Zong, H. (2014) Generation and applications of MADM-based mouse genetic mosaic system. Chapter in Mouse Genetics. Methods in Molecular Biology Series, Vol. 1194:187-201. Shree Ram Singh, Vincenzo Coppola (Eds.) Humana Press and Springer
Galvão RP, Zong H. (2013) Inflammation and Gliomagenesis: Bi-Directional Communication at Early and Late Stages of Tumor Progression. PubMed PMC3607461[Available on 2014/3/1]
Liu, C., Zong, H. (2012) Developmental origins of brain tumors. Current Opinion in Neurobiology, 22(5):844-9 PubMedPMC
Zong, H.*, Verhaak, R.G.W., Canoll, P. (2012) The cellular origin for malignant glioma and prospects for clinical advancements. Expert Review of Molecular Diagnostics, 12(4):383-394 PubMedPMC
Collaborative papers
Brain tumor research
Jecrois ES, Zheng W, Bornhorst M, … Zong H, Packer RJ, Zhu Y (2021) Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors. Developmental Cell, doi: 10.1016/j.devcel.2021.08.004.• Jecrois ES, Zheng W, Bornhorst M, … Zong H, Packer RJ, Zhu Y (2021) Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors. Developmental Cell, doi: 10.1016/j.devcel.2021.08.004.
Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP. (2020) Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles. Cell Reports, 30(8):2489-2500
Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y. (2019) Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas. Cancer Research, 79(19):4814-4827
Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis S Deguchi, K Katsushima, A Hatanaka, K Shinjo, F Ohka, T Wakabayashi, … Oncogene 36 (32), 4629
Papagiannakopoulos, T., Friedmann-Morvinski, D., Neveu, P., Dugas, J.C., Gill, R.M., Huillard, E., Liu, C., Zong, H., Rowitch, D.H., Barres, B.A., Verma, I.M., Kosik, K.S. (2011) Pro-neuronal miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene, 31(15):1884-1895 PubMed
Applications of the MADM system
Lineage-dependent spatial and functional organization of the mammalian enteric nervous system R Lasrado, W Boesmans, J Kleinjung, C Pin, D Bell, L Bhaw, S McCallum, …Science 356 (6339), 722-726
Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis P Riccio, C Cebrian, H Zong, S Hippenmeyer, F Costantini PLoS biology 14 (2), e1002382
Packard A, Georgas K, Michos O, Riccio P, Cebrian C, Combes AN, Ju A, Ferrer-Vaquer A, Hadjantonakis AK, Zong H, Little MH, Costantini F.(2013) Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud. PubMed
Foo, L.C., Allen, N.J., Bushong, E.A., Ventura, P.B., Chung, W.S., Zhou, L., Cahoy, J.D., Daneman, R., Zong, H., Ellisman., M.H., Barres, B.A. (2011) Development of a Method for the Purification and Culture of Rodent Astrocytes. Neuron, 71:799-811 PubMedPMC
Hippenmeyer, S., Youn, Y.H., Moon, H.M., Miyamichi, K., Zong, H., Wynshaw-Boris, A., Luo, L. (2010) Genetic Mosaic Dissection of Lis1 and Ndel1 in Neuronal Migration. Neuron, 68:695-709 PubMedPMC
Development of genetic tools
Gay, L., Miller, M.R., Ventura, P.B., Devasthali, V., Vue, Z., Thompson, H.L., Temple, S., Zong, H., Cleary, M.D., Stankunas, K., Doe, C.Q. (2013) Mouse TU-tagging: a chemical/genetic intersectional method for purifying cell type specific nascent RNA. Genes and Development, 27:98–115 PubMed
Tasic, B., Miyamichi, K., Hippenmeyer, S., Sani, V.S., Zeng, H., Joo, W., Zong, H., Chen-Tsai, Y., Luo, L. (2012) Extensions of MADM (Mosaic Analysis with Double Markers) in Mice. PLoS One, 7(3):e33332 PubMedPMC
Tasic, B., Hippenmeyer, S., Wang, C., Gamboa, M., Zong, H., Chen-Tsai, Y., Luo, L. (2011) Site-specific integrase-mediated transgenesis in mice via pronuclear injection. PNAS, 108: 7902–7907 PubMedPMC
