Klibanov, Alexander L.

Alexander L. Klibanov

Alexander L. Klibanov

Primary Appointment

Associate Professor, Medicine: Cardiovascular Medicine

Education

  • MS, Chemistry, Moscow State University, Moscow Russia
  • PhD, Biochemistry, USSR Cardiology Research Center, Moscow, Russia

Contact Information

639 Nettle Court
Charlottesville, VA 22908
Telephone: 434-243-9773
Email: alk6n@virginia.edu

Research Interests

Targeted delivery of therapeutic and diagnostic imaging agents.

Research Description

Ultrasound imaging is a widespread and inexpensive non-invasive diagnostic technique. Ultrasound contrast agents offer a flexible platform that can be used for diagnostic imaging as a blood pool marker (tissue perfusion), as a targeted marker for imaging of inflammation, angiogenesis, and also as adjunct microdevices for enhanced targeted drug delivery and gene therapy. In diagnostic imaging, detection of contrast material offers high sensitivity (individual micron-sized particles can be visualized in vitro and in vivo by ultrasound medical imaging systems). We prepare and analyze such ultrasound contrast materials, attach targeting ligands (antibodies, peptides) and plasmid DNA to their surface for targeting and ultrasound-enhanced delivery. Using colloid chemistry-based approaches, stable microbubbles with extended circulation lifetime are designed; polymer brush coating is applied to ensure enhanced stability.

Selected Publications