Alexander L. Klibanov
Primary AppointmentAssociate Professor, Medicine: Cardiovascular Medicine
- MS, Chemistry, Moscow State University, Moscow Russia
- PhD, Biochemistry, USSR Cardiology Research Center, Moscow, Russia
Targeted delivery of therapeutic and diagnostic imaging agents.
In diagnostic imaging, detection of contrast material offers high sensitivity (individual micron-sized particles can be visualized in vitro and in vivo by ultrasound medical imaging systems). We prepare and analyze such ultrasound contrast materials, attach targeting ligands (antibodies, peptides) and plasmid DNA to their surface for targeting and ultrasound-enhanced delivery. Using colloid chemistry-based approaches, stable microbubbles with extended circulation lifetime are designed; polymer brush coating is applied to ensure enhanced stability.