Isakson, Brant

Brant  Isakson

Brant Isakson

Primary Appointment

Associate Professor, Molecular Physiology and Biological Physics

Education

  • PhD, University of Wyoming

Contact Information


Telephone: 4-9039
Email: bei6n@virginia.edu

Research Interests

Intercellular communication in normal and disease state vasculature.

Research Description

My lab focuses on intercellular communication in the microvasculature and how this regulates the critical proces of vessel dilation and constriction--elucidating this fundamental proces is key to understanding such diseases as hypertention and the associated vascular dysfunction seen with obesity.

To that end, our lab is keenly interested in the membrane bound proteins connexins (which link cellular cytoplasm together physically) and pannexins (which signal other cells by releasing ATP into the extracellular environment), as well as how nitric oxide may regulate these channels directly, or act independantly based on it's cellular localization in the vessel wall.

Our lab utilizes everything from gene knockout animals and isolated intact blood vessels, to unique cell culture techniques and molecular biology, to biphysical techniques such as analytical size exclusion.  We believe this is the best way to tackle the most pressing and interesting biological questions.

Lastly, we strive to place creativity over dogma.

Selected Publications