Helmy M. Siragy
Biology and Pathophysiology of Angiotensin Receptor Subtypes in the Kidney and Heart Diseases
The lab focuses on the biology and pathophysiology of angiotensin subtype receptors in cardiovascular systems. Currently the lab is conducting pioneering translational research that has major clinical impact and is related to cardiac ischemia, diabetic kidney disease, local tissue production of aldosterone and its paracrine functions in the kidney and heart.
Our Lab is also involved in clinical studies related to aldosterone pulse activity in normal individuals and in patients with primary aldosteronism, vasopressin receptors in the kidney and management of hyponatremia, and ongoing studies investigating the effects of long term angiotensin subtype 1 receptor blockade on cardiovascular morbidity and mortality.