John H. Bushweller
Primary AppointmentProfessor, Molecular Physiology and Biological Physics
- BA, Chemistry, Dartmouth College, Hanover, NH
- PhD, Chemistry, University of California, Berkeley, CA
- Postdoc, Eidgenössische Technische Hochschule, Zürich, Switzerland
Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins
Structure-Based Drug Discovery. We are using structure-based drug design to develop small molecule inhibitors of the oncoprotein forms of core binding factor. Our focus is on the development of highly targeted molecules which inactivate the oncoprotein form and have minimal side-effects. Such agents have significant potential for the treatment of the associated leukemias.
Structural Studies of Membrane Proteins. A third focus for the lab is the application of solution NMR methods to the structure determination of membrane proteins. The vast majority of drug targets are membrane-embedded proteins. This class of proteins has presented significant challenges for structure determination by any method. We determined the structure of OmpA by solution NMR which established a paradigm for tackling this class of proteins by solution NMR. We are currently examining additional technical improvements in this area as well as targeting several new systems for structure determination.
Please see our group website for additional information: http://www.people.virginia.edu/~jhb4v/