Primary AppointmentAssistant Professor, Biomedical Engineering
- BA, Chemistry, Hamilton College, Clinton NY
- PhD, Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Advancement in the design of imaging agents has many far-reaching implications for the future directions of molecular imaging and radiological sciences including the following: (1) The early detection of disease (e.g. atherosclerosis, cancer, etc.) by the identification of early molecular signatures; (2) The evaluation of various treatments and therapeutics (i.e. efficacy and dosing); and (3) The high-throughput screening of various compounds during pharmaceutical development. I am interested in applying powerful combinatorial approaches to the development and design of targeted, multimodal, and amplifiable imaging agents. Using this method of attack, I have generated imaging agents capable of the early detection in vivo of colon, pancreatic, lung, and prostate cancers as well as specific targets in atherosclerosis and inflammation. These agents have also been used to evaluate therapeutic response at the molecular level in vivo. In addition to the generation of imaging agents, the hits" identified from these approaches represent a snapshot of the proteome in aberrant cells and are useful for the delineation of the underlying signal transduction pathways important to disease progression. Therefore