Loren D. Erickson
Primary AppointmentAssociate Professor, Microbiology, Immunology, and Cancer Biology
- BA, Biology, Seattle Pacific University
- PhD, Immunology, The University of Iowa
- Postdoc, Immunology, Dartmouth Medical School
Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus and multiple myeloma; Immunotherapeutics in the treatment of B cell disorders
B lymphocytes constitute a major cellular component of the immune system, whose function is to produce secreted proteins called antibodies that protect the host against pathogens. A hallmark of this antibody-based protection is the capacity of specialized B cells, plasma cells (PC), to have a prolonged lifespan and is the raison d'être for vaccines to establish long-term immunity. In healthy individuals, the persistence of PCs is an asset for protective humoral immunity but is a significant liability in PC disorders. Thus, understanding the factors that determine PC development and survival takes on considerable importance in terms of both biology and therapeutics. Our laboratory studies two PC disorders: first, is the PC malignancy, multiple myeloma (MM) and second, is the antibody-mediated autoimmune disease, systemic lupus erythematosus.
Go to Loren Erickson?s Lab Site for detailed information about his lab and his research.