R. Ariel Gomez
Primary AppointmentProfessor, Pediatrics: Nephrology
Ontogeny of renin-angiotensis system, differentiation of the JG cell.
Renin-synthesizing cells are crucial in the regulation of blood pressure and fluid and electrolyte homeostasis. These cells have been considered as terminally differentiated because they synthesize a hormone, are few in numbers, and their restricted juxtaglomerular (JG) localization. However, during embryonic development, and kidney morphogenesis, renin cells are widely distributed and do not become circumscribed to a classical" JG localization until later in postnatal life. In addition