Cohn, Steven M.

Steven M. Cohn

Steven M. Cohn

Primary Appointment

Professor, Medicine: Gastroenterology and Hepatology

Contact Information

MultiStory 2141
Charlottesville, VA 22908
Telephone: 243-2718

Research Interests

Communication between the Immune System and Epithelium in Chronic Inflammatory Intestinal Diseases.

Research Description

Dr. Cohn's research is centered on understanding communication between the immune

system and the epithelium in inflammatory bowel disease and other chronic inflammatory

diseases of the intestine. A major focus of his research is on understanding how

cytokines, growth factors, and other inflammatory mediators regulate the fate

of epithelial stem cells and their descendents in the intestine following injury.

These studies may have a great impact on the development of new therapeutic approaches

to enhance restoration of the mucosal barrier in diseases such as Crohn's disease

and Ulcerative colitis.

Another area of investigation for Dr. Cohn is understanding how prostaglandins

and other inflammatory mediators effect the development of cancer in the intestine.

When injured by carcinogens in the food we eat, epithelial stem cells may either

undergo apoptosis or attempt to repair the damage that these compounds cause.

Evidence is emerging that prostaglandins and inflammatory cytokines may regulate

which pathway a stem cell takes after carcinogen exposure. The objective of

this area of research is to develop new chemopreventive agents for reducing

the incidence of colorectal cancer by shifting the balance between apoptosis

and cellular repair pathways in the epithelial stem cell population.

Dr. Cohn is also a member of the Beirne

B. Carter Center for Immunology Research.

Selected Publications