Steven M. Cohn
Primary AppointmentProfessor, Medicine: Gastroenterology and Hepatology
Communication between the Immune System and Epithelium in Chronic Inflammatory Intestinal Diseases.
Another area of investigation for Dr. Cohn is understanding how prostaglandins and other inflammatory mediators effect the development of cancer in the intestine. When injured by carcinogens in the food we eat, epithelial stem cells may either undergo apoptosis or attempt to repair the damage that these compounds cause. Evidence is emerging that prostaglandins and inflammatory cytokines may regulate which pathway a stem cell takes after carcinogen exposure. The objective of this area of research is to develop new chemopreventive agents for reducing the incidence of colorectal cancer by shifting the balance between apoptosis and cellular repair pathways in the epithelial stem cell population.
Dr. Cohn is also a member of the Beirne B. Carter Center for Immunology Research.