Slobodan M. Todorovic
- MD, Medicine, University of Belgrade School of Medicine
- PhD, Pharmacology, University of Illinois
- Residency, Anesthesiology, Washington University
Pharmacology and function of T-type (low-voltage-activated, LVA) calcium channels in sensory transmission.
My research involves biophysical techniques to measure membrane currents (voltage clamp and current clamp recordings) from acutely dissociated rat sensory neurons and intact brain and spinal cord slices. We have cell lines available that express recombinant ion channel proteins which allow studies of the relationship between structure and function. At the system level, we collaborate with Dr. Jevtovic-Todorovic lab to directly examine the effects of Ca2+ channel modulators on pain sensation following injection into peripheral receptive fields of sensory neurons in intact rats and rats with mechanically (chronic constrictive injury)- or metabolically (diabetic)-induced peripheral neuropathy, as well as knockout mice lacking T-type channels.
Our future studies will investigate how modulation of T-type Ca2+ channels in sensory and CNS neurons affects their function and how different anesthetic, analgesic and anticonvulsant agents selectively target particular classes of voltage-gated Ca2+ channels. In particular, we are interested in testing new selective T-type channel blockers in vitro recordings from DRG and thalamic cells, as well as functional studies of nociception and anesthetic end points in vivo.
Our research is funded by NIH research grants from NINDS and NIGMS.