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Agaisse Lab

The Agaisse Lab is associated with the Department of Microbiology, Immunology, and Cancer Biology (MIC). Our laboratory studies the bacterial pathogen Shigella flexneri, which causes approximately 270 million cases of bacillary dysentery (blood in stool) worldwide every year, resulting in more than 200,000 deaths. Our objective is to understand the molecular and cellular mechanisms supporting the disease in order to rationally design therapeutic interventions. We utilize a multi-disciplinary approach integrating molecular and cellular microbiology, high-throughput imaging, live confocal microscopy, bacterial and host cell genomics, bioinformatics and unique animal models of pathogenesis.

 

Want to Join our Team?

We currently have positions available for talented scientists at the undergraduate, graduate and post-graduate levels.

Congratulations Ella!

Undergrad Researcher Ella Reithinger in the Agaisse lab at MIC won first place at the 41st Annual Richard D. Katz Distinguished Majors Biology Symposium! Recently graduating from the University of Virginia, she obtained a B.S. in Biology with highest distinction. She will soon be attending the University of Cambridge as a Rotary Global Grant Scholar to pursue an MPhil in Population Health Sciences. In the Agaisse lab, her research project aimed to elucidate the role and regulation of Shigella flexneri virulence proteins, such as IcsA and IpgB1.

 

Congratulations Steven!

Dr. Steven Rolland won the Audience Choice Award for the Lighting Talk Competition at the 2025 Postdoc Research Symposium organized by the Postdoctoral Association of UVA in collaboration with Virginia Tech on 21st May, 2025. His talk entitled ‘Colon Under Attack: Investigating how Shigella Invades and Spreads’ explained his research findings on cell-to-cell spread in host-pathogen interactions which was the most voted for by the audience.

Hello 2025!

Agaisse lab welcomes two of its newest members, Ms Mahua Mandal who is lab’s manager and Dr Songyu Dong who is our newest postdoc!