Bertram, Edward H.
- BA, Zoology/German, University of North Carolina at Chapel Hill
- MD, Medicine, University of North Carolina
Experimental Pathology, Translational Science
Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.
This laboratory is using a new animal model of chronic limbic epilepsy to investigate the natural history of untreated epilepsy. This study will provide the basis for examining a variety of factors which may affect long-term outcome. In addition, the functional anatomy of limbic seizures is under investigation to determine which brain regions are critical to the generation of spontaneous seizures. These studies include the evaluation of physiologic and anatomic interactions among these areas to determine how normal function and connectivity may be altered to achieve this pathologic state.
Clinical investigation centers on the evaluation of patients for surgical treatment of intractable epilepsy, concentrating on improving monitoring and imaging techniques that will better localize the epileptogenic region. These studies involve investigators from neurosurgery, neuroradiology, neuropathology, neuropsychology, and biomedical engineering.