Stefanie Redemann

Redemann, Stefanie

Primary Appointment

Assistant Professor, Molecular Physiology and Biological Physics

Contact Information

480 Ray C. Hunt Drive
Charlottesville, Va 22903
Telephone: 4342431413
Email: sz5j@virginia.edu
Website: https://med.virginia.edu/redemann-lab/

Research Disciplines

Biophysics, Cell and Developmental Biology

Research Interests

Chromosome segregation and aneuploidy in meiosis and mitosis

Research Description

Mitotic spindles are highly dynamic, microtubule based constructions that function to segregate the chromosomes during cell division. The dynamic properties of microtubules in spindles are modulated by many factors, including polymerases, depolymerases, motor proteins, cross-linkers and other microtubule associated proteins, of which many are conserved throughout eukaryotic organisms. Despite this evolutionary conservation of essential factors, there is a remarkable variability in spindle organization and mechanics between organisms and tissues within species.

The Redemann Lab is interested in uncovering and understanding the underlying principles of spindle assembly on a nano-scale level.

We are using a combination of large scale 3D reconstruction of spindles by electron tomography and state-of-the-art light microscopy to investigate the mechanisms and principles of spindle assembly and chromosome segregation. Ultimately we are using the dynamic and ultra structural data to develop and test models of spindle formation and mechanics.

List of Publications in Pubmed

Selected Publications