Associate Professor, Molecular Physiology and Biological Physics
- BS, Chemistry, Tsinghua University
- PhD, Chemical Biology, University of Alberta
- Postdoc, Chemical Biology, The Scripps Research Institute
Biochemistry, Biology, Biophysics, Biophysics & Structural Biology, Biotechnology, Cancer Biology, Cell and Developmental Biology, Chemistry, Molecular Biology, Molecular Pharmacology, Neuroscience, Physiology, Translational Science
Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Our laboratory uses interdisciplinary approaches in chemistry, engineering, biophysics, and physiology to study and manipulate complex biological systems, with a focus on the development of novel molecular biosensors to peer into cells and organisms to understand biosignaling and communications. We use a collection of technologies, such as protein engineering, fluorescence imaging, bioluminescence imaging, synthetic chemistry, electrophysiology, and MRI to dissect biological pathways related to metabolism, redox biology, insulin receptor signaling, and neurotransmission. Our immediate goal is to monitor biological signaling in real time with excellent spatial resolution and molecular precision in physiologically relevant environments. Our long-term goal is to apply these new probes to live cells and rodent models to understand communications relevant to diabetes, cognition and behavior, and neurological disorders. In addition, we are interested in development of vaccines and protein based drugs for infectious diseases and diabetes.
List of Publications in Pubmed