Publications

Li W, Jiang H. Analysis of Phase-Separated Biomolecular Condensates in Cancer. Methods Mol Biol. 2023;2660:345-356. doi: 10.1007/978-1-0716-3163-8_23. PubMed PMID: 37191808; NIHMSID:NIHMS1907634.

Jiang H, Stukenberg T. Emerging roles of liquid-liquid phase separation and membraneless organelles in cancer progression. Chapter 24 in “Droplets of Life: Membrane-less Organelles, Biomolecular Condensates, and Biological Liquid-Liquid Phase Separation”. Elsevier Press, 2023, P651-662, https://www.sciencedirect.com/science/article/pii/B978012823967400004X. https://doi.org/10.1016/B978-0-12-823967-4.00004-X

Zhao Y, Hao X, Li Z, Feng X, Katz J, Michalek SM, Jiang H, Zhang P. Role of chromatin modulator Dpy30 in osteoclast differentiation and function. Bone. 2022 Jun;159:116379. doi: 10.1016/j.bone.2022.116379. Epub 2022 Mar 16. PubMed PMID: 35307321; PubMed Central PMCID: PMC9063347.

Li W, Jiang H. Nuclear Protein Condensates and Their Properties in Regulation of Gene Expression. J Mol Biol. 2022 Jan 15;434(1):167151. doi: 10.1016/j.jmb.2021.167151. Epub 2021 Jul 14. Review. PubMed PMID: 34271007; PubMed Central PMCID: PMC9012237.

Shi B, Li W, Jiang H. Epigenetic condensates regulate chromatin activity and tumorigenesis. Mol Cell Oncol. 2021;8(5):1997040. doi: 10.1080/23723556.2021.1997040. eCollection 2021. PubMed PMID: 34859151; PubMed Central PMCID: PMC8632315.

Shi B, Li W, Song Y, Wang Z, Ju R, Ulman A, Hu J, Palomba F, Zhao Y, Le JP, Jarrard W, Dimoff D, Digman MA, Gratton E, Zang C, Jiang H. UTX condensation underlies its tumour-suppressive activity. Nature. 2021 Sep;597(7878):726-731. doi: 10.1038/s41586-021-03903-7. Epub 2021 Sep 15. PubMed PMID: 34526716; PubMed Central PMCID: PMC9008583.

Jiang H. Granulation of m1A-modified mRNAs protects their functionality through cellular stress. J Mol Cell Biol. 2021 Feb 15;12(11):821-822. doi: 10.1093/jmcb/mjaa073. PubMed PMID: 33377971; PubMed Central PMCID: PMC7883821.

Li W, Jiang H. Regulation of tumorigenic splicing by protein condensates with specific biophysical properties. Mol Cell Oncol. 2020 Oct 10;7(6):1819753. doi: 10.1080/23723556.2020.1819753. PubMed PMID: 33235917; PubMed Central PMCID: PMC7671046.

Yang Z, Jiang H. A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells. Cell Mol Life Sci. 2020 Oct;77(20):4031-4047. doi: 10.1007/s00018-020-03522-x. Epub 2020 Apr 21. Review. PubMed PMID: 32318759; PubMed Central PMCID: PMC7541408.

Li W, Hu J, Shi B, Palomba F, Digman MA, Gratton E, Jiang H. Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis. Nat Cell Biol. 2020 Aug;22(8):960-972. doi: 10.1038/s41556-020-0550-8. Epub 2020 Jul 27. PubMed PMID: 32719551; PubMed Central PMCID: PMC7425812.

Jiang H. The complex activities of the SET1/MLL complex core subunits in development and disease. Biochim Biophys Acta Gene Regul Mech. 2020 Jul;1863(7):194560. doi: 10.1016/j.bbagrm.2020.194560. Epub 2020 Apr 15. Review. PubMed PMID: 32302696; PubMed Central PMCID: PMC7236065.

Shah K, King GD, Jiang H. A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells. J Mol Cell Biol. 2020 Jan 22;12(1):4-16. doi: 10.1093/jmcb/mjz036. PubMed PMID: 31065682; PubMed Central PMCID: PMC7052987.

Shah KK, Whitaker RH, Busby T, Hu J, Shi B, Wang Z, Zang C, Placzek WJ, Jiang H. Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth. Exp Cell Res. 2019 Sep 15;382(2):111485. doi: 10.1016/j.yexcr.2019.06.030. Epub 2019 Jun 26. PubMed PMID: 31251903; PubMed Central PMCID: PMC6717027.

Yang Z, Shah K, Khodadadi-Jamayran A, Jiang H. Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity. Stem Cell Reports. 2019 Jul 9;13(1):61-75. doi: 10.1016/j.stemcr.2019.05.023. Epub 2019 Jun 20. PubMed PMID: 31231026; PubMed Central PMCID: PMC6627005.

Yang Z, Shah K, Busby T, Giles K, Khodadadi-Jamayran A, Li W, Jiang H. Hijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer. J Clin Invest. 2018 Aug 1;128(8):3605-3618. doi: 10.1172/JCI97072. Epub 2018 Jul 23. PubMed PMID: 29870403; PubMed Central PMCID: PMC6063490.

Hu J, Khodadadi-Jamayran A, Mao M, Shah K, Yang Z, Nasim MT, Wang Z, Jiang H. AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors. Nat Commun. 2016 Nov 8;7:13347. doi: 10.1038/ncomms13347. PubMed PMID: 27824034; PubMed Central PMCID: PMC5105168.

Yang Z, Shah K, Khodadadi-Jamayran A, Jiang H. Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells. J Exp Med. 2016 Oct 17;213(11):2349-2364. doi: 10.1084/jem.20160185. Epub 2016 Sep 19. PubMed PMID: 27647347; PubMed Central PMCID: PMC5068233.

Yang Z, Augustin J, Hu J, Jiang H. Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS One. 2015;10(12):e0145336. doi: 10.1371/journal.pone.0145336. eCollection 2015. PubMed PMID: 26691508; PubMed Central PMCID: PMC4686221.

Yang Z, Augustin J, Chang C, Hu J, Shah K, Chang CW, Townes T, Jiang H. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood. 2014 Sep 25;124(13):2025-33. doi: 10.1182/blood-2014-01-549220. Epub 2014 Aug 18. PubMed PMID: 25139354; PubMed Central PMCID: PMC4507038.

Jiang H, Lu X, Shimada M, Dou Y, Tang Z, Roeder RG. Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95. Nat Struct Mol Biol. 2013 Oct;20(10):1156-63. doi: 10.1038/nsmb.2656. Epub 2013 Sep 1. PubMed PMID: 23995757; PubMed Central PMCID: PMC3813012.

Jiang H, Shukla A, Wang X, Chen WY, Bernstein BE, Roeder RG. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell. 2011 Feb 18;144(4):513-25. doi: 10.1016/j.cell.2011.01.020. PubMed PMID: 21335234; PubMed Central PMCID: PMC3572774.

Jiang H, Chang FC, Ross AE, Lee J, Nakayama K, Nakayama K, Desiderio S. Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. Mol Cell. 2005 Jun 10;18(6):699-709. doi: 10.1016/j.molcel.2005.05.011. PubMed PMID: 15949444.

Jiang H, Ross AE, Desiderio S. Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins. J Biol Chem. 2004 Feb 27;279(9):8478-86. doi: 10.1074/jbc.M311219200. Epub 2003 Dec 4. PubMed PMID: 14660558.