Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

3/25/2024

UVA Author: Josh Wythe Citation: Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen…

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal

3/25/2024

UVA Author: Laura Newman Citation: Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S,…

Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

6/14/2023

UVA Author: Nicholas Chavkin Citation: Acharya BR, Fang JS, Jeffery ED, Chavkin NW, Genet G, Vasavada H, Nelson EA, Sheynkman GM, Humphries MJ, Hirschi KK. Connexin 37 sequestering of activated-ERK…

Rational engineering of lung alveolar epithelium

6/14/2023

UVA Author: Karen Hirschi Citation: Leiby KL, Yuan Y, Ng R, Raredon MSB, Adams TS, Baevova P, Greaney AM, Hirschi KK, Campbell SG, Kaminski N, Herzog EL, Niklason LE. Rational…

Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice

6/14/2023

UVA Author: Karen Hirschi Citation: Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation…

MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis

6/14/2023

UVA Author: Yinyu Wu Citation: Wu Y, Paila U, Genet G, Hirschi KK. MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis. Dev Cell. 2023 Jun 6:S1534-5807(23)00240-X. doi: 10.1016/j.devcel.2023.05.007. Epub…

Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data

4/24/2023

UVA Author: Karen Hirschi Citation: de Souza VBC, Jordan BT, Tseng E, Nelson EA, Hirschi KK, Sheynkman G, Robinson MD. Transformation of alignment files improves performance of variant callers for…

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation

4/21/2023

UVA Author: Elias Spiliotis Citation: Radler MR, Liu X, Peng M, Doyle B, Toyo-Oka K, Spiliotis ET. Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia…

Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in breast cancer cells

4/21/2023

UVA Author: Elias Spiliotis Citation: Devlin L, Okletey J, Perkins G, Bowen JR, Nakos K, Montagna C, Spiliotis ET. Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in…

A septin GTPase scaffold of dynein-dynactin motors triggers retrograde lysosome transport

4/21/2023

UVA Author: Elias Spiliotis Citation: Kesisova IA, Robinson BP, Spiliotis ET. A septin GTPase scaffold of dynein-dynactin motors triggers retrograde lysosome transport. J Cell Biol. 2021 Feb 1;220(2):e202005219. doi: 10.1083/jcb.202005219.…