Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest

6/14/2023

UVA Author: Nicholas Chavkin Citation: Acharya BR, Fang JS, Jeffery ED, Chavkin NW, Genet G, Vasavada H, Nelson EA, Sheynkman GM, Humphries MJ, Hirschi KK. Connexin 37 sequestering of activated-ERK…

Rational engineering of lung alveolar epithelium

6/14/2023

UVA Author: Karen Hirschi Citation: Leiby KL, Yuan Y, Ng R, Raredon MSB, Adams TS, Baevova P, Greaney AM, Hirschi KK, Campbell SG, Kaminski N, Herzog EL, Niklason LE. Rational…

Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice

6/14/2023

UVA Author: Karen Hirschi Citation: Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation…

MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis

6/14/2023

UVA Author: Yinyu Wu Citation: Wu Y, Paila U, Genet G, Hirschi KK. MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis. Dev Cell. 2023 Jun 6:S1534-5807(23)00240-X. doi: 10.1016/j.devcel.2023.05.007. Epub…

Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data

4/24/2023

UVA Author: Karen Hirschi Citation: de Souza VBC, Jordan BT, Tseng E, Nelson EA, Hirschi KK, Sheynkman G, Robinson MD. Transformation of alignment files improves performance of variant callers for…

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation

4/21/2023

UVA Author: Elias Spiliotis Citation: Radler MR, Liu X, Peng M, Doyle B, Toyo-Oka K, Spiliotis ET. Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia…

Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in breast cancer cells

4/21/2023

UVA Author: Elias Spiliotis Citation: Devlin L, Okletey J, Perkins G, Bowen JR, Nakos K, Montagna C, Spiliotis ET. Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in…

A septin GTPase scaffold of dynein-dynactin motors triggers retrograde lysosome transport

4/21/2023

UVA Author: Elias Spiliotis Citation: Kesisova IA, Robinson BP, Spiliotis ET. A septin GTPase scaffold of dynein-dynactin motors triggers retrograde lysosome transport. J Cell Biol. 2021 Feb 1;220(2):e202005219. doi: 10.1083/jcb.202005219.…

Septins guide noncentrosomal microtubules to promote focal adhesion disassembly in migrating cells

4/21/2023

UVA Author: Elias Spiliotis Citation: Merenich D, Nakos K, Pompan T, Donovan SJ, Gill A, Patel P, Spiliotis ET, Myers KA. Septins guide noncentrosomal microtubules to promote focal adhesion disassembly…

Septins mediate a microtubule-actin crosstalk that enables actin growth on microtubules

4/21/2023

UVA Author: Elias Spiliotis Citation: Nakos K, Alam MNA, Radler MR, Kesisova IA, Yang C, Okletey J, Tomasso MR, Padrick SB, Svitkina TM, Spiliotis ET. Septins mediate a microtubule-actin crosstalk…