Cellular Dynamics

All living cells are dynamic machines that integrate a wide variety of biochemical and mechanical information, continuously adapting and responding to their local environment. Signals transmitted by hormones, growth factors, neighboring cells or the extracellular matrix are sensed by cells and can trigger rapid changes in metabolism, gene expression, cell shape/cytoskeletal organization, membrane dynamics and behavior. For example, cell migration in response to external cues involves the dynamic reorganization of the actin, microtubule and intermediate filament cytoskeletons, coordinated with membrane trafficking events that deliver new membrane to the leading edge and internalize adhesive receptors from the cell rear. In all cells, the targeted delivery of receptors, transporters, secretory and endocytic cargo to the appropriate destination is essential for cell function. Many of these processes are disrupted or dysregulated in human disease, and many pathogenic microorganisms manipulate host cell cytoskeleton or membrane dynamics to establish a reproductive niche.

Researchers in the Department of Cell Biology explore cellular dynamics using a variety of model systems ranging from cultured cells to Drosophila, zebrafish, Xenopus and mouse models. Employing state-of-the-art imaging, biochemical, biophysical and genetic approaches, our goals are to visualize and analyze cellular events at high resolution and in real time. We seek to clarify the underlying forces and mechanisms that interact to drive cellular behavior. These studies, which emphasize fundamental cellular processes, are also essential for understanding how perturbations alter their course and may lead to disease.

Faculty

James Casanova

Casanova, James E.

Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.<br> Cell Biology of bacterial pathogenesis. <br>The innate immune response to bacterial infection.


J. Castle

Castle, J. David

Intracellular cholesterol and the regulation of insulin secretion and membrane trafficking.


Douglas DeSimone

DeSimone, Douglas W.

Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis


Noelle Dwyer

Dwyer, Noelle

Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance


Sarah Kucenas

Kucenas, Sarah C.

The role of glia in the development, maintenance and regeneration of the nervous system


Eyleen O'Rourke

O’Rourke, Eyleen Jorgelina

Obesity and Aging


Kenneth Pfister

Pfister, K. Kevin

Regulation of Cytoplasmic Dynein for Membrane Bounded Organelle Trafficking in Axons


Kodi Ravichandran

Ravichandran, Kodi S.

Apoptotic cell clearance mechanisms in health and disease


Stefanie Redemann

Redemann, Stefanie

Spindle assembly, the structure function relation and the basics of the huge variability of spindle size, architecture and mechanics between different tissues as well as different species


Dorothy Schafer

Schafer, Dorothy A.

Mechanisms of actin assembly during cell migration and membrane traffic


Jung-Bum Shin

Shin, Jung-Bum

Auditory Neurobiology


P. Todd Stukenberg

Stukenberg, P. Todd

Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors


Lukas Tamm

Tamm, Lukas K.

Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions


Judith White

White, Judith M.

Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics


Bettina Winckler

Winckler, Bettina

Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.