Cellular Basis of Disease, Biotechnology & Translation
All biomedical science is pursued with the goal of translating laboratory discoveries towards the enhancement of human health, perhaps as diagnostics or preventive or curative therapeutics. With perturbations of the cell – the basic unit of life – at the heart of all human diseases, many of the major advances in medicine, such as treatments for atherosclerosis and diabetes, have stemmed from fundamental observations made by cell biologists.
Advances take years to become clinically relevant. Current translational stage projects in the Department of Cell Biology include Judy White’s discovery of basic molecular aspects of virus entry into cells that has led to an NIH collaboration to repurpose FDA approved drugs for the treatment of emerging viral infections including Ebola. Gordon Laurie’s discovery of basic cell biological aspects of the eye is leading to a novel treatment for dry eye syndromes. Curiosity driven Departmental research is laying the foundation for emerging health technologies.
Further, the Department is actively educating the next generation of translational scientists. It does so through the NIGMS funded Biotechnology Training Program, hosted by the Department and directed by Gordon Laurie, and through The Essentials of Translational Sciences course with faculty involvement from the Darden School of Business, UVa Licensing and Ventures and from the Virginia Center for Translational and Regulatory Sciences.
Barker, Thomas H.
Matrix Biology and Engineering
Bloom, George S.
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Casanova, James E.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Keller, Susanna R.
Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology
Architecture and function of biological membranes
Laurie, Gordon W.
Restoration of Homeostasis in Disease
Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure
O’Rourke, Eyleen Jorgelina
Obesity and Aging
Stukenberg, P. Todd
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling