Research in Biotechnology at UVA brings together researchers from all biomedical, engineering, and chemical sciences at UVA to promote state-of-the-art collaborative science. From this innovative science comes conceptual breakthroughs and new products.In 2000, we established a Biotechnology Training Program (BTP) at UVA with the goal of providing fertile ground for the development of future leaders in science and technology. It is one of only 19 BTPs nationwide. Our graduates are scientific leaders at major biotechnology companies, federal agencies, and foundations, and lead independent research labs at universities, or are postdoctoral scientists at institutions nationwide.
The BTP offers many enhancements. The 2 – 3 month company externship training is transformative. Some students alter career plans towards academia or industrial research. Others affirm prior career directions or receive unexpected offers of employment. All make important contributions, some publish articles, and invariably the collaboration enhances thesis projects. Venues are worldwide, from Boston to San Francisco to Australia, England, Holland, Finland, Germany, Spain and Sweden.
We also offer company tours – including Merck, Pfizer, BD; panel discussions with industrial leaders – including BTP alumni; as well as seminars and biannual symposia that gather recognized innovators under the umbrella of a broad scientific theme.
Our outstanding mentors from across the sciences at UVA are award-winning leaders in their fields, with success in nurturing the best from our students. Many hold patents, and several have started companies. This is an exciting time for our students to be at the frontlines of science and technology.
Identify and target key genomic and epigenomic drivers in cancer
Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Epigenetic and genetic mechanisms underlying metabolic disease
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Regeneration and Developmental Biology of the Hearing and Balance Organs in the Vertebrate Ear.
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Structure-function relationships in proteins
Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Innate immunity, chronic disease, host-parasite interactions
Bacterial attachment and biofilms, microbial transport in porous media
Basement Membrane Structure and Metalloproteinases
Super-resolution fluorescence imaging of bacterial cells
The Structural Biology of HIV assembly
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Immune response to infectious disease in the CNS
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Nanotechnologies for targeted drug delivery
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy
Neural tissue engineering, biomaterials, drug delivery, redox regulation of stem cell fate, engineering cell-interactive microenvironments
Bioanalytical Chemistry on Microchips
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
Vascular and Molecular Engineering
Neuronal Vulnerability: A Study of Cellular Mechanism
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Developmental regulation of planar cell polarity in the mammalian nervous system
Chemical biology of sphingosine 1-phosphate
Pathogenicity of Francisella tularensis and vaccines
The Cause and Consequence of Somatic Mosaicism in Neurons
Atherosclerosis, Obesity, Diabetes
Molecular pathogenesis and genomic analysis of human cancers
Regulation and function of tyrosine phosphorylation in complex networks
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Protein Evolution; Computational Biology
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Immune mechanisms of defense against enteric (diarrheal) infections
Bioanalytical tools for inflammatory disease
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Human Immunodeficiency; Virus Gene Expression
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Molecular and bioelectric devices; tissue regeneration.
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.
Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics
Neural Circuits in Healthy and Diseased Brains
Early detection, cancer prevention, and tumor microenvironment
Single Cell Analysis