Bioinformatics & Genomics

Research in Bioinformatics and Genomics at UVA uses quantitative methods to describe the behavior of genes, genomes, and biological systems.At the intersection of experimental and computational biology, genomics research involves interpretation and integration of large-scale, genome-wide datasets.

These approaches are being applied to diverse topics in biology and medicine including cancer genomics, human and model organism genetics, epigenetics, and evolution. Active areas of research at the University of Virginia include whole-genome sequencing, cancer genome evolution, disease gene mapping, personalized medicine, gene expression profiling, epigenome mapping, high-throughput functional genetics, genome annotation, protein evolution, and pathway reconstruction.

Genomics and bioinformatics research often requires the development of new techniques, including both experimental protocols and data analysis algorithms, to enable a deeper understanding of complex biological systems. In this respect, the field is entering a new and exciting era; rapidly improving “next-generation” DNA sequencing technologies now allow for the routine sequencing of entire genomes and transcriptomes, or of virtually any targeted set of DNA or RNA molecules.

The exponential explosion of genomic data fueled by these technologies presents an unprecedented opportunity to elucidate the molecular underpinnings of natural variation and human disease, but the sheer abundance and complexity of these data also pose significant and unsolved bioinformatic challenges. The scope of these opportunities and challenges promises to revolutionize biology and medicine.

Faculty
  • Adli, Mazhar

    Identify and target key genomic and epigenomic drivers in cancer

  • Auble, David T.

    Molecular Mechanisms of Transcriptional Regulation

  • Bekiranov, Stefan

    Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks

  • Bender, Timothy P.

    Regulation of gene expression during lymphocyte development

  • Bochkis, Irina

    Epigenetic and genetic mechanisms underlying metabolic disease

  • Brown, Michael G.

    Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation

  • Chen, Wei-Min

    Statistical genetics and genomics.

  • Civelek, Mete

    Systems Genetics Approaches to Understand Cardiometabolic Traits

  • Dutta, Anindya

    Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer

  • Farber, Charles R.

    Systems Genetics of Skeletal Development and Maintenance

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Garrett-Bakelman, Francine

    Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression

  • Grainger, Robert M.

    Molecular embryology–gene regulation in cells committed to specific developmental lineages

  • Guertin, Michael

    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Hockensmith, Joel W.

    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria

  • Holmes, Jeffrey W.

    Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.

  • Janes, Kevin A.

    Systems-biology approaches to cancer biology and virology.

  • Jiang, Hao

    Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

  • Kasson, Peter M.

    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Kucenas, Sarah C.

    The role of glia in the development, maintenance and regeneration of the nervous system

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Loughran, Jr., Thomas P

    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)

  • Manichaikul, Ani W.

    Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis

  • McConnell, Michael J

    The Cause and Consequence of Somatic Mosaicism in Neurons

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • Minor, Wladek

    Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific
    Reproducibility

  • Mura, Cameron

    Structure, function & evolution of RNA-processing assemblies; structural and computational biology; molecular biophysics

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • O’Rourke, Eyleen Jorgelina

    Obesity and Aging

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Parichy, David

    Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates

  • Pearson, William R.

    Protein Evolution; Computational Biology

  • Ratan, Aakrosh

    Genomics, Molecular Evolution, Algorithm Design and Analysis

  • Rekosh, David M.

    Human Immunodeficiency; Virus Gene Expression

  • Rich, Stephen S.

    Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis

  • Sheffield, Nathan

    computational biology & bioinformatics; high performance computing; epigenomics & chromatin; pediatric cancer; computational regulatory genomics; machine learning

  • Wang, Yuh-Hwa

    Genome instability in cancer and repeat expansion diseases

  • Zang, Chongzhi

    Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics

  • Zunder, Eli

    Stem Cell Behavior