Biochemistry
About
Research in Biochemistry at UVA seeks to identify biologically relevant molecules and study their synthesis, degradation, and role in biological processes.Since molecules interact in complex ways in living organisms, modern biochemical research is a collaborative, interdisciplinary effort. Approaches that are used include molecular biology, genetics, epigenetics, bioinformatics, computational biology, structural biology, and many others. More than 60 faculty from these areas form our robust and dedicated group of mentors in biochemistry.
Research in biochemistry at UVA ranges from computational analysis to clinical applications for cancer and cardiovascular disease. Biochemical studies of interacting proteins, DNA, and sub-cellular structures in normal and disease states provide a wide array of research opportunities. This research, coupled with a broad collection of graduate courses, furnish our students with the skills and background necessary for successful careers in biomedical research and education.
Faculty
Abbas, Tarek A.
The Ubiquitin System and Human Cancer
Abounader, Roger
Basic and translational brain tumor research
Ai, Huiwang
Molecular Biosensors; Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Auble, David T.
Molecular Mechanisms of Transcriptional Regulation
Bao, Huan
Biophysics of membrane pore formation; research and therapeutic applications of lipid nanoparticles.
Bielinsky, Anja Katrin
Genome instability syndromes in cancer and immune deficiencies
Bourne, Philip E
Data Science
Chalfant, Charles Edward
Hematology and Oncology, Cell Biology, Lipid Signaling, Cancer Cell Signaling, and RNA Biology
Columbus, Linda
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Creutz, Carl E.
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Derewenda, Zygmunt S.
Structure-function relationships in proteins
Ebrahim, Seham
Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging
Egelman, Edward H.
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Fallahi-Sichani, Mohammad
Cancer systems biology, Single-cell quantitative biology, Computational modeling
Felder, Robin A.
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Flowers, Sarah
Impact of APOE and lipid metabolism on cell function in Alzheimer's disease.
Fox, Jay W.
Basement Membrane Structure and Metalloproteinases
Garcia-Blanco, Mariano A.
RNA-protein interactions in antiviral immunity and autoimmune diseases.
Gaultier, Alban
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Gioeli, Daniel
Signal transduction in cancer cells
Goldfarb, Adam N.
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Harris, Thurl E
Molecular mechanisms controlling insulin signaling and fat synthesis.
Hendrickson, Eric A
Hematology & Oncology
Jiang, Hao
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
Jomaa, Ahmad
Localisation of nascent proteins to sub-cellular compartments
Kasson, Peter M.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Kendall, Melissa M.
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Levental, Ilya
Composition, Biophysics and Physiology of Cellular Membranes
Liu, Wenpeng
Genetic and Epigenetic stability in human cancer
Lu, Xiaowei
Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure
Lynch, Kevin R.
Chemical biology of sphingosine 1-phosphate
Mayo, Marty W.
Transcriptional Regulation by NFKB
Mohi, Golam
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
Naegle, Kristen
Regulation and function of tyrosine phosphorylation in complex networks
Park, Kwon-Sik
Mechanisms of tissue/organ homeostasis and tumorigeensis
Paschal, Bryce M.
Nuclear Transport, Signaling, and Cancer
Pemberton, Lucy F.
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Ramakrishnan, Girija
Microbial Pathogenesis
Rekosh, David M.
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Schulman, Ira G.
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Shin, Jung-Bum
Auditory Neurobiology
Smith, Jeffrey S.
Transcriptional Silencing and Aging in Yeast
Spiliotis, Elias T
Spatial Cell Biology. Neuronal Morphogenesis and Disease. Cancer Migration and Invasion.
Stukenberg, P. Todd
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Tang, Shangming
Complex Genome Rearrangements
Trinh, Bon Q
Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases
Tsihlis, Nick
Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery
Walsh, Kenneth
Clonal hematopoiesis: A new mechanism of cardiovascular disease
Wang, Yuh-Hwa
Genome instability in cancer and repeat expansion diseases
Wotton, David
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Zeitlin, Scott O.
Mechanisms of Huntington's Disease Pathogenesis
Zhang, Tian
Integrating high-throughput proteomic, chemical, genetic and computational tools for target identification and drug discovery in cancer biology
Zimmer, Jochen
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.
Zimring, James C
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
Zunder, Eli
Single Cell Analysis