Biochemistry

Research in Biochemistry at UVA seeks to identify biologically relevant molecules and study their synthesis, degradation, and role in biological processes.Since molecules interact in complex ways in living organisms, modern biochemical research is a collaborative, interdisciplinary effort. Approaches that are used include molecular biology, genetics, epigenetics, bioinformatics, computational biology, structural biology, and many others.  More than 60 faculty from these areas form our robust and dedicated group of mentors in biochemistry.

Research in biochemistry at UVA ranges from computational analysis to clinical applications for cancer and cardiovascular disease. Biochemical studies of interacting proteins, DNA, and sub-cellular structures in normal and disease states provide a wide array of research opportunities.  This research, coupled with a broad collection of graduate courses, furnish our students with the skills and background necessary for successful careers in biomedical research and education.

Faculty
  • Abbas, Tarek A.

    The Ubiquitin System and Human Cancer

  • Adli, Mazhar

    Identify and target key genomic and epigenomic drivers in cancer

  • Ai, Huiwang

    Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics

  • Auble, David T.

    Molecular Mechanisms of Transcriptional Regulation

  • Bhatnagar, Sanchita

    Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome

  • Bloom, George S.

    Pathogenic mechanisms in Alzheimer’s Disease and other neurodegenerative disorders

  • Bochkis, Irina

    Epigenetic and genetic mechanisms underlying metabolic disease

  • Bushweller, John H.

    Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins

  • Cafiso, David S.

    Molecular Mechanisms for Membrane Transport and Cell Signaling

  • Columbus, Linda

    Biophysical Chemistry: Membrane protein structure, function, and dynamics

  • Creutz, Carl E.

    Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis

  • Deppmann, Christopher

    Elucidating and Understanding the Mechanisms Underlying Nervous System Development

  • Derewenda, Zygmunt S.

    Structure-function relationships in proteins

  • Desai, Bimal N.

    Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis

  • Egelman, Edward H.

    Structure and Function of Macromolecular Complexes Using Electron Microscopy

  • Engel, Daniel A.

    Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

  • Ewald, Sarah

    Innate immunity, chronic disease, host-parasite interactions

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Fox, Jay W.

    Basement Membrane Structure and Metalloproteinases

  • Gahlmann, Andreas

    Super-resolution fluorescence imaging of bacterial cells

  • Ganser-Pornillos, Barbie

    The Structural Biology of HIV assembly

  • Gioeli, Daniel

    Signal transduction in cancer cells

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Grant, Patrick A.

    Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer

  • Guertin, Michael

    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Harris, Thurl E

    Molecular mechanisms controlling insulin signaling and fat synthesis.

  • Hockensmith, Joel W.

    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria

  • Hsu, Ku-Lung

    Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry

  • Jiang, Hao

    Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

  • Kashatus, David F

    The Role of Mitochondrial Fusion and Fission in Tumorigenesis.

  • Kasson, Peter M.

    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Laurie, Gordon W.

    Role of Prosecretory Mitogen ‘Lacritin’ in Epithelial Homeostasis, Secretion and Innate Defense

  • Leitinger, Norbert

    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Lukens, John R.

    Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders

  • Lynch, Kevin R.

    Chemical biology of sphingosine 1-phosphate

  • Manichaikul, Ani W.

    Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis

  • Mayo, Marty W.

    Transcriptional Regulation by NFKB

  • McConnell, Michael J

    The Cause and Consequence of Somatic Mosaicism in Neurons

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • Mohi, Golam

    Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.

  • Mura, Cameron

    Structure, function & evolution of RNA-processing assemblies; structural and computational biology; molecular biophysics

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • Nakamoto, Robert K.

    Structure-Function of Active Transporters

  • O’Rourke, Eyleen Jorgelina

    Obesity and Aging

  • Park, Kwon-Sik

    Mechanisms of organ development and homeostasis and tumor development

  • Paschal, Bryce M.

    Nuclear Transport, Signaling, and Cancer

  • Pemberton, Lucy F.

    Nuclear Transport in Chromatin Assembly and Transcriptional Regulation

  • Pornillos, Owen

    Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system

  • Ramakrishnan, Girija

    Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis

  • Ravichandran, Kodi S.

    Apoptotic cell clearance mechanisms in health and disease

  • Rekosh, David M.

    Human Immunodeficiency; Virus Gene Expression

  • Schafer, Dorothy A.

    Mechanisms of actin assembly during cell migration and membrane traffic

  • Schulman, Ira G.

    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

  • Shin, Jung-Bum

    Auditory Neurobiology

  • Smith, Jeffrey S.

    Transcriptional Silencing and Aging in Yeast

  • Stukenberg, P. Todd

    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

  • Tamm, Lukas K.

    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

  • Vande Pol, Scott B.

    How Viruses, Particularly Papillomaviruses, Can Cause Cancer

  • Wang, Yuh-Hwa

    Genome instability in cancer and repeat expansion diseases

  • White, Judith M.

    Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics

  • Wiener, Michael C.

    Structure/function of integral membrane proteins; structural biophysics; enzymology and virology of ZMPSTE24; sparse-constraint structure determination; technology development

  • Wotton, David

    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

  • Zeitlin, Scott O.

    Mechanisms of Huntington’s Disease Pathogenesis

  • Zimmer, Jochen

    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.

  • Zunder, Eli

    Stem Cell Behavior