Research in Biochemistry at UVA seeks to identify biologically relevant molecules and study their synthesis, degradation, and role in biological processes.Since molecules interact in complex ways in living organisms, modern biochemical research is a collaborative, interdisciplinary effort. Approaches that are used include molecular biology, genetics, epigenetics, bioinformatics, computational biology, structural biology, and many others. More than 60 faculty from these areas form our robust and dedicated group of mentors in biochemistry.
Research in biochemistry at UVA ranges from computational analysis to clinical applications for cancer and cardiovascular disease. Biochemical studies of interacting proteins, DNA, and sub-cellular structures in normal and disease states provide a wide array of research opportunities. This research, coupled with a broad collection of graduate courses, furnish our students with the skills and background necessary for successful careers in biomedical research and education.
The Ubiquitin System and Human Cancer
Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Molecular Mechanisms of Transcriptional Regulation
Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Epigenetic and genetic mechanisms underlying metabolic disease
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Molecular Mechanisms for Membrane Transport and Cell Signaling
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Structure-function relationships in proteins
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Ebola, SARS-CoV-2, Influenza and Zika
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Basement Membrane Structure and Metalloproteinases
Super-resolution fluorescence imaging of bacterial cells
The Structural Biology of HIV assembly
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Molecular mechanisms controlling insulin signaling and fat synthesis.
Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Systems-biology approaches to cancer biology and virology.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Nanotechnologies for targeted drug delivery
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Chemical biology of sphingosine 1-phosphate
Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis
Transcriptional Regulation by NFKB
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Structure, function & evolution of RNA-processing assemblies; structural and computational biology; molecular biophysics
Regulation and function of tyrosine phosphorylation in complex networks
Structure-Function of Active Transporters
Obesity and Aging
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Mechanisms of organ development and homeostasis and tumor development
Nuclear Transport, Signaling, and Cancer
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Apoptotic cell clearance mechanisms in health and disease
Human Immunodeficiency; Virus Gene Expression
Mechanisms of actin assembly during cell migration and membrane traffic
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Transcriptional Silencing and Aging in Yeast
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
The role of clonal hematopoiesis in cardio-metabolic disease processes
Genome instability in cancer and repeat expansion diseases
Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
Structure/function of integral membrane proteins; structural biophysics; enzymology and virology of ZMPSTE24; sparse-constraint structure determination; technology development
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Mechanisms of Huntington's Disease Pathogenesis
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.
Single Cell Analysis