Research in Cardiovascular Disease at UVA focuses on mechanisms that contribute to major cardiovascular diseases such as atherosclerosis, aneurysms, hypertension, peripheral vascular disease, heart failure, myocardial infarction, and stroke.Over 150 former trainees now hold leadership positions in academia, industry, and other biomedical science-related disciplines. Students perform research in one of the many laboratories housed in our world-renowned Robert M. Berne Cardiovascular Research Center (CVRC). Training is augmented through our NIH-funded Cardiovascular Research Training Program, which prepares students for highly successful biomedical research careers in a broad range of areas, including studies of basic cardiovascular development and function. Our research also focuses on the development of novel drugs, devices, diagnostic methods, imaging modalities, and other therapeutic approaches to better diagnose, prevent, or treat cardiovascular disease.
Neurobiology of the autonomic nervous system and the homeostatic control of breathing
Molecular Physiology and Biological Physics
Systems Genetics Approaches to Understand Cardiometabolic Traits
Epigenetic mechanisms involved in complex human disease
Tumor microenvironment and mechanisms of tumor neovascularization
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Pathophysiological mechanisms and impact of cell state transitions
Molecular mechanisms controlling insulin signaling and fat synthesis.
Understanding Cellular and Molecular Mechanisms Leading to Blood Vessel Formation
Translating our discoveries in the microcirculation to tangible benefits in patients.
RNA regulatory networks and RNA binding proteins during cardiovascular development and in cardiovascular disease
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation to identifying therapeutic targets.
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Immune System Regulation of Cardiometabolic Disease
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.
Identify the calcium signaling abnormalities that lead to vascular dysfunction and blood pressure elevation in cardiovascular disorders
Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery
Clonal hematopoiesis: A new mechanism of cardiovascular disease
Toward better understanding of and innovative therapies for peripheral vascular diseases
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
Cardiovascular Development and Cerebrovascular Pathologies
Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.
Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus