Research in Infectious Diseases at UVA provides rich interdisciplinary experiences in the molecular biology, immunology, epidemiology, and pathogenesis of infectious diseases as well as vaccine development, therapeutics and diagnostic technologies for infectious agents. Trainees have opportunities to conduct research with over 30 different mentors from eight different departments
The Infectious Diseases (ID) Training Program is currently in its 4th decade of consecutive NIH funding. This program brings together an internationally recognized clinical program in infectious diseases and international health and superb basic molecular and cellular biologists. The core philosophy of the program is that interactions between basic scientists and clinicians in training and research will spark innovative approaches to diagnose, treat and prevent infections
A basic philosophy of the program is that through interactions of basic scientists and clinicians in research and training, will come the breakthrough science that leads to new interventions to diagnose, treat and prevent infections.
The Infectious Diseases Training Program features side-by-side education of predoctoral students, M.D.s, and Ph.D. postdoctoral fellows. Training is enriched by research-in-progress sessions, seminar series, and journal clubs that integrate both clinical and basic research aspects of infectious diseases.
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Regulation of gene expression during lymphocyte development
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Herpes Simplex Virus Infection of Neurons
Cellular and molecular mechanisms of Neisserial pathogenesis
Host/pathogen Interaction - Chlamydia Infection
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
Innate immunity, chronic disease, host-parasite interactions
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Immune response to infectious disease in the CNS
Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria
Systems-biology approaches to cancer biology and virology.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Nanotechnologies for targeted drug delivery
Developmental regulation of planar cell polarity in the mammalian nervous system
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Pathogenicity of Francisella tularensis and vaccines
Host-pathogen interactions; molecular parasitology; mucosal inflammation; immunopathology and repair. Our research interests evolved from studying a parasite that causes inflammation of the gut, similar to IBD.
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Immune mechanisms of defense against enteric (diarrheal) infections
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
Human Immunodeficiency; Virus Gene Expression
Molecular and bioelectric devices; tissue regeneration.
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.