Infectious Disease

biodefenseResearch in Infectious Diseases at UVA provides rich interdisciplinary experiences in the molecular biology, immunology, epidemiology, and pathogenesis of infectious diseases as well as vaccine development, therapeutics and diagnostic technologies for infectious agents.  Trainees have opportunities to conduct research with over 30 different mentors from eight different departments

The Infectious Diseases (ID) Training Program is currently in its 4th decade of consecutive NIH funding. This program brings together an internationally recognized clinical program in infectious diseases and international health and superb basic molecular and cellular biologists.  The core philosophy of the program is that interactions between basic scientists and clinicians in training  and research will spark innovative approaches to diagnose, treat and prevent infections

A basic philosophy of the program is that through interactions of basic scientists and clinicians in research and training, will come the breakthrough science that leads to new interventions to diagnose, treat and prevent infections.

The Infectious Diseases Training Program features side-by-side education of predoctoral students, M.D.s, and Ph.D. postdoctoral fellows. Training is enriched by research-in-progress sessions, seminar series, and journal clubs that integrate both clinical and basic research aspects of infectious diseases.

Faculty
  • Agaisse, Hervé

    Genetic approaches, cellular and molecular biology of intracellular pathogen infection

  • Bender, Timothy P.

    Regulation of gene expression during lymphocyte development

  • Braciale, Thomas J.

    T Lymphocyte Responses To Virus Infection

  • Brown, Michael G.

    Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation

  • Bullock, Timothy N.

    Pathways to enhance T cell function in tumors.

  • Casanova, James E.

    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.

  • Cliffe, Anna

    Herpes Simplex Virus Infection of Neurons

  • Criss, Alison K.

    Cellular and molecular mechanisms of Neisserial pathogenesis

  • Derré, Isabelle

    Host/pathogen Interaction – Chlamydia Infection

  • Egelman, Edward H.

    Structure and Function of Macromolecular Complexes Using Electron Microscopy

  • Engel, Daniel A.

    Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

  • Ewald, Sarah

    Innate immunity, chronic disease, host-parasite interactions

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Hahn, Young S.

    Immune regulation for HCV infection and chronic liver inflammation

  • Hammarskjöld, Marie-Louise

    Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses

  • Harris, Tajie H.

    Immune response to infectious disease in the CNS

  • Hockensmith, Joel W.

    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria

  • Janes, Kevin A.

    Systems-biology approaches to cancer biology and virology.

  • Kasson, Peter M.

    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.

  • Kedes, Dean H.

    Human Herpes virus associated with malignancy, including Kaposi’s Sarcoma

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Lu, Xiaowei

    Developmental regulation of planar cell polarity in the mammalian nervous
    system

  • Lukens, John R.

    Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders

  • Mann, Barbara J.

    Pathogenicity of Francisella tularensis and vaccines

  • Moonah, Shannon N.

    Host-pathogen interactions; molecular parasitology; mucosal inflammation; immunopathology and repair

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Petri, William A.

    Immune mechanisms of defense against enteric (diarrheal) infections

  • Pornillos, Owen

    Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system

  • Ramakrishnan, Girija

    Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis

  • Rekosh, David M.

    Human Immunodeficiency; Virus Gene Expression

  • Swami, Nathan

    Molecular and bioelectric devices; tissue regeneration.

  • Tamm, Lukas K.

    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

  • White, Judith M.

    Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics

  • Zeichner, Steven L.

    Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.

  • Zimmer, Jochen

    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.