Chemistry and Physics of Living Systems
Research in the Chemistry and Physics of Living Systems aims to take a quantitative, rigorous approach to molecular cell biology. Our faculty investigate broad areas of molecular biology including gene regulation, macromolecular synthesis, molecular transport, cellular organization, and how cells make decisions. This research relies on advanced methods in analytical chemistry (mass spectrometry, NMR), biophysics (electron microscopy, computer simulations), and advanced imaging (super-resolution microscopy, single-molecule tracking). Our aim is to provide fundamental insights into biological processes across scales from molecular to organismal and address the most pressing problems in biomedicine and biotechnology. Our faculty span across many departments at UVA, forming a diverse and integrated group of teachers and mentors.
Molecular Biosensors; Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Molecular Mechanisms for Membrane Transport and Cell Signaling
Biophysical Chemistry: Membrane protein structure, function, and dynamics
The design of self-assembling nanomaterials
Super-resolution fluorescence imaging of bacterial cells
Translating our discoveries in the microcirculation to tangible benefits in patients.
Localisation of nascent proteins to sub-cellular compartments
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Precision medicine, translational science, regeneration, organoids, high resolution imaging, computational modeling
Neural tissue engineering, biomaterials, drug delivery, redox regulation of stem cell fate, engineering cell-interactive microenvironments
Composition, Biophysics and Physiology of Cellular Membranes
Chromosome segregation and aneuploidy in meiosis and mitosis
Proteoform Systems Biology: proteogenomic approaches to uncover the role of proteomic variation in human disease
Molecular and bioelectric devices; tissue regeneration.
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Molecular Imaging; Cancer Immunology; Vaccines; Antibiotic Resistance.
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.