Research in Immunology at UVA includes research spanning basic development and regulation of the immune system to clinical trials. Areas of interest include molecular aspects of B and T lymphocyte development, innate immunity, regulation of immune response quality, lymphocyte trafficking, modulation of immunity to viruses and bacteria, tumor immunology and immunotherapy, allergic diseases, autoimmunity, neuroimmunology and immunological perturbations in cardiovascular disease.The Immunology Training Program consists of outstanding faculty, students and post-doctoral fellows performing cutting-edge research in a collaborative and collegial environment. We provide students with an interdisciplinary training experience that emphasizes the breadth of immunology as well as cell and molecular biology. The Training Program is funded in part by an NIH training grant in its 17th year, with 32 mentors providing cohesion and comprehensiveness.
The Program is integrated with and supported by the Department of Microbiology, Immunology, and Cancer Biology (MIC), the Carter Immunology Center, and the Center for Immunity, Inflammation, and Regenerative Medicine. It also provides access to many state-of the-art research support facilities.
The program provides a creative and vibrant training environment that prepares students for careers in immunology research and the delivery of new and innovative therapies to patients.
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Regulation of gene expression during lymphocyte development
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Signaling Pathways and Breast Cancer
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Herpes Simplex Virus Infection of Neurons
Cellular and molecular mechanisms of Neisserial pathogenesis
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Innate immunity, chronic disease, host-parasite interactions
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Immune response to infectious disease in the CNS
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Nanotechnologies for targeted drug delivery
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Atherosclerosis, Obesity, Diabetes
Immune mechanisms of defense against enteric (diarrheal) infections
Bioanalytical tools for inflammatory disease
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Apoptotic cell clearance mechanisms in health and disease
Human Immunodeficiency; Virus Gene Expression
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
Cellular and molecular mechanisms of allergic disease in humans.
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
Single Cell Analysis