Research in Immunology at UVA includes research spanning basic development and regulation of the immune system to clinical trials. Areas of interest include molecular aspects of B and T lymphocyte development, innate immunity, regulation of immune response quality, lymphocyte trafficking, modulation of immunity to viruses and bacteria, tumor immunology and immunotherapy, allergic diseases, autoimmunity, neuroimmunology and immunological perturbations in cardiovascular disease.The Immunology Training Program consists of outstanding faculty, students and post-doctoral fellows performing cutting-edge research in a collaborative and collegial environment. We provide students with an interdisciplinary training experience that emphasizes the breadth of immunology as well as cell and molecular biology. The Training Program is funded in part by an NIH training grant in its 17th year, with 32 mentors providing cohesion and comprehensiveness.
The Program is integrated with and supported by the Department of Microbiology, Immunology, and Cancer Biology (MIC), the Carter Immunology Center, and the Center for Immunity, Inflammation, and Regenerative Medicine. It also provides access to many state-of the-art research support facilities.
The program provides a creative and vibrant training environment that prepares students for careers in immunology research and the delivery of new and innovative therapies to patients.
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Engineering cancer-killing T cells to overcome obstacles in solid tumors
Innate immunity, Cell clearance, Inflammatory and autoimmune disease
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Bouton, Amy H.
Signaling Pathways and Breast Cancer
Braciale, Thomas J.
T Lymphocyte Responses To Virus Infection
Brown, Michael G.
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Bullock, Timothy N.
Pathways to enhance T cell function in tumors.
Casanova, James E.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Chalfant, Charles Edward
Hematology and Oncology, Cell Biology, Lipid Signaling, Cancer Cell Signaling, and RNA Biology
Herpes Simplex Virus Infection of Neurons
Cowardin, Carrie A.
The maternal and infant microbiome in childhood growth and immunity
Criss, Alison K.
Cellular and molecular mechanisms of Neisserial pathogenesis
Cross, Janet V.
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Desai, Bimal N.
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Systems Immunology, Cancer Systems Biology, , Neonatal and Maternal Immunology
Engelhard, Victor H.
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Erickson, Loren D.
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Garcia-Blanco, Mariano A.
RNA-protein interactions in antiviral immunity and autoimmune diseases.
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Hahn, Young S.
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Harris, Tajie H.
Immune response to infectious disease in the CNS
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Kedes, Dean H.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Laubach, Victor E.
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation to identifying therapeutic targets.
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Loughran, Jr., Thomas P
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Luckey, Chance John
Lukens, John R.
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
McNamara, Coleen A.
Immune System Regulation of Cardiometabolic Disease
Petri, William A.
Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections
Bioanalytical tools for inflammatory disease
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Rekosh, David M.
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Rich, Stephen S.
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Immune Responses in asthma, pulmonary fibrosis, and lung injury.
Viral immunology, T cells, Macrophages, Tissue repair
Regulation of cell-surface stability and intracellular trafficking of membrane proteins in epithelial cells
Woodfolk, Judith A.
The immune response to common cold and allergens in health and disease.
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Advanced machine learning; Theoretical and computational biophysic
Zeichner, Steven L.
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Zimring, James C
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
Single Cell Analysis