Research in Cancer Biology at UVA focuses on cutting-edge basic, translational, and clinical research in a highly collaborative environment. Our research is significantly enhanced by being part of an NCI-designated Cancer Center whose mission is in part to discover the fundamental causes of cancer and develop new knowledge into tools for cancer treatment, diagnosis, and prevention. For over 35 years the University of Virginia Cancer Training Program has been preparing students for productive careers in academia, industry and education. Students pursue research under world-renowned faculty in areas such as cancer cell signaling, genetics and epigenetics, chemical and structural biology, immunology and immunotherapy, inflammation and cancer, and interactions between tumor cells and non-transformed stromal components of the tumor microenvironment.
Integration of student training with the UVA NCI-designated Cancer Center provides an exceptional opportunity to prepare students for leadership roles in all aspects of cancer research and to ultimately shape the future of this rapidly expanding area of biomedical research. Students work closely with research teams in women’s oncology, lung cancer, gastrointestinal cancers, hematopoietic malignancies and stem cell research. This research is augmented by state-of-the-art research and clinical facilities that deliver new and innovative therapies to patients.
The Ubiquitin System and Human Cancer
Basic and translational brain tumor research
Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Regulation of gene expression during lymphocyte development
Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
Signaling Pathways and Breast Cancer
Pathways to enhance T cell function in tumors.
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Tumor microenvironment and mechanisms of tumor neovascularization
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer; Bioinformatics of cancer outcome
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Macrophage effector functions in inflammation and immunotherapy
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Basement Membrane Structure and Metalloproteinases
Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Regeneration and Systemic Responses to Tissue Damage
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Molecular mechanisms controlling insulin signaling and fat synthesis.
Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Systems-biology approaches to cancer biology and virology.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Nanotechnologies for targeted drug delivery
Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Neuronal Vulnerability: A Study of Cellular Mechanism
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Developmental regulation of planar cell polarity in the mammalian nervous system
Identification of Novel Biomarkers for Inflammatory Myopathies
Transcriptional Regulation by NFKB
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Molecular pathogenesis and genomic analysis of human cancers
Regulation and function of tyrosine phosphorylation in complex networks
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates
Mechanisms of organ development and homeostasis and tumor development
Nuclear Transport, Signaling, and Cancer
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Bioanalytical tools for inflammatory disease
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Genomics, Molecular Evolution, Algorithm Design and Analysis
Apoptotic cell clearance mechanisms in health and disease
Human Immunodeficiency; Virus Gene Expression
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Mechanisms of actin assembly during cell migration and membrane traffic
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
computational biology & bioinformatics; high performance computing; epigenomics & chromatin; pediatric cancer; computational regulatory genomics; machine learning
Tailored fit targeting approaches: Cancer Immunotherapy, Antibodies and conjugates
Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Molecular and bioelectric devices; tissue regeneration.
Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Genome instability in cancer and repeat expansion diseases
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.
Early detection, cancer prevention, and tumor microenvironment
Single Cell Analysis