Cancer Biology

cancer cellResearch in Cancer Biology at UVA focuses on cutting-edge basic, translational, and clinical research in a highly collaborative environment.  Our research is significantly enhanced by being part of an NCI-designated Cancer Center whose mission is in part to discover the fundamental causes of cancer and develop new knowledge into tools for cancer treatment, diagnosis, and prevention. For over 35 years the University of Virginia Cancer Training Program has been preparing students for productive careers in academia, industry and education.  Students pursue research under world-renowned faculty in areas such as cancer cell signaling, genetics and epigenetics, chemical and structural biology, immunology and immunotherapy, inflammation and cancer, and interactions between tumor cells and non-transformed stromal components of the tumor microenvironment.

Integration of student training with the UVA NCI-designated Cancer Center provides an exceptional opportunity to prepare students for leadership roles in all aspects of cancer research and to ultimately shape the future of this rapidly expanding area of biomedical research.  Students work closely with research teams in women’s oncology, lung cancer, gastrointestinal cancers, hematopoietic malignancies and stem cell research.  This research is augmented by state-of-the-art research and clinical facilities that deliver new and innovative therapies to patients.

Faculty
  • Abbas, Tarek A.

    The Ubiquitin System and Human Cancer

  • Abounader, Roger

    Basic and translational brain tumor research

  • Adli, Mazhar

    Identify and target key genomic and epigenomic drivers in cancer

  • Ai, Huiwang

    Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics

  • Bekiranov, Stefan

    Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks

  • Bender, Timothy P.

    Regulation of gene expression during lymphocyte development

  • Bhatnagar, Sanchita

    Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome

  • Bouton, Amy H.

    Signaling Pathways and Breast Cancer

  • Bullock, Timothy N.

    Pathways to enhance T cell function in tumors.

  • Bushweller, John H.

    Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins

  • Caliari, Steven

    Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment

  • Casanova, James E.

    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.

  • Cross, Janet V.

    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention

  • Dudley, Andrew

    Tumor microenvironment and mechanisms of tumor neovascularization

  • Dutta, Anindya

    Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer

  • Dwyer, Noelle

    Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance

  • Engelhard, Victor H.

    Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity

  • Erickson, Loren D.

    Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders

  • Fox, Jay W.

    Basement Membrane Structure and Metalloproteinases

  • Garrett-Bakelman, Francine

    Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression

  • Gioeli, Daniel

    Signal transduction in cancer cells

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Grant, Patrick A.

    Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer

  • Guertin, Michael

    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Halme, Adrian J.

    Regeneration and Systemic Responses to Tissue Damage

  • Hammarskjöld, Marie-Louise

    Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses

  • Hockensmith, Joel W.

    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria

  • Hsu, Ku-Lung

    Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry

  • Hu, Song

    Photoacoustic imaging, light microscopy, neuroscience, cardiovascular biology, cancer, regenerative medicine

  • Janes, Kevin A.

    Systems-biology approaches to cancer biology and virology.

  • Jiang, Hao

    Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

  • Kashatus, David F

    The Role of Mitochondrial Fusion and Fission in Tumorigenesis.

  • Kedes, Dean H.

    Human Herpes virus associated with malignancy, including Kaposi’s Sarcoma

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Landen, Charles

    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies

  • Lazo, John S.

    The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases

  • Lazzara, Matthew

    Cellular Engineering

  • Lee, Kevin S.

    Neuronal Vulnerability: A Study of Cellular Mechanism

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Loughran, Jr., Thomas P

    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)

  • Lu, Xiaowei

    Developmental regulation of planar cell polarity in the mammalian nervous
    system

  • Mandell, James W.

    Identification of Novel Biomarkers for Inflammatory Myopathies

  • Mayo, Marty W.

    Transcriptional Regulation by NFKB

  • Mohi, Golam

    Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.

  • Moskaluk, Christopher A.

    Molecular pathogenesis and genomic analysis of human cancers

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • Owens, Gary K.

    Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

  • Parichy, David

    Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates

  • Park, Kwon-Sik

    Mechanisms of organ development and homeostasis and tumor development

  • Paschal, Bryce M.

    Nuclear Transport, Signaling, and Cancer

  • Pemberton, Lucy F.

    Nuclear Transport in Chromatin Assembly and Transcriptional Regulation

  • Pompano, Rebecca

    Bioanalytical tools for inflammatory disease

  • Price, Richard J.

    Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis

  • Purow, Benjamin W.

    Novel therapeutic approaches to brain cancers and to other neurologic diseases

  • Ratan, Aakrosh

    Genomics, Molecular Evolution, Algorithm Design and Analysis

  • Ravichandran, Kodi S.

    Apoptotic cell clearance mechanisms in health and disease

  • Rekosh, David M.

    Human Immunodeficiency; Virus Gene Expression

  • Rutkowski, Melanie

    Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis

  • Schafer, Dorothy A.

    Mechanisms of actin assembly during cell migration and membrane traffic

  • Schulman, Ira G.

    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

  • Sheffield, Nathan

    computational biology & bioinformatics; high performance computing; epigenomics & chromatin; pediatric cancer; computational regulatory genomics; machine learning

  • Singh, Jogender Tushir

    Tailored fit targeting approaches: Cancer Immunotherapy, Antibodies and conjugates

  • Smith, M. Mitchell

    Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle

  • Stukenberg, P. Todd

    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

  • Swami, Nathan

    Molecular and bioelectric devices; tissue regeneration.

  • Thisse, Christine I.

    Molecular Mechanisms of Early Vertebrate Development and Morphogenesis.
    Application to Stem Cell Biology and Regenerative Medicine

  • Vande Pol, Scott B.

    How Viruses, Particularly Papillomaviruses, Can Cause Cancer

  • Wang, Yuh-Hwa

    Genome instability in cancer and repeat expansion diseases

  • Wotton, David

    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

  • Zang, Chongzhi

    Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics

  • Zeichner, Steven L.

    Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.

  • Zimmer, Jochen

    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.

  • Zong, Hui

    Early detection, cancer prevention, and tumor microenvironment

  • Zunder, Eli

    Stem Cell Behavior