Research in Cancer Biology at UVA focuses on cutting-edge basic, translational, and clinical research in a highly collaborative environment. Our research is significantly enhanced by being part of an NCI-Designated Comprehensive Cancer Center whose mission is in part to discover the fundamental causes of cancer and develop new knowledge into tools for cancer treatment, diagnosis, and prevention. For over 35 years the University of Virginia Cancer Training Program has been preparing students for productive careers in academia, industry and education. Students pursue research under world-renowned faculty in areas such as cancer cell signaling, genetics and epigenetics, chemical and structural biology, immunology and immunotherapy, inflammation and cancer, and interactions between tumor cells and non-transformed stromal components of the tumor microenvironment.
Integration of student training with the UVA NCI-designated Cancer Center provides an exceptional opportunity to prepare students for leadership roles in all aspects of cancer research and to ultimately shape the future of this rapidly expanding area of biomedical research. Students work closely with research teams in women’s oncology, lung cancer, gastrointestinal cancers, hematopoietic malignancies and stem cell research. This research is augmented by state-of-the-art research and clinical facilities that deliver new and innovative therapies to patients.
The Ubiquitin System and Human Cancer
Basic and translational brain tumor research
Engineering cancer-killing T cells to overcome obstacles in solid tumors
Tumor cell migration, invasion, metastasis, growth factor signalling
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Genome instability syndromes in cancer and immune deficiencies
Signaling Pathways and Breast Cancer
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Molecular Physiology and Biological Physics
Engineering biomaterials as cellular microenvironments
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Hematology and Oncology, Cell Biology, Lipid Signaling, Cancer Cell Signaling, and RNA Biology
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Tumor microenvironment and mechanisms of tumor neovascularization
Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging
Macrophage effector functions in inflammation and immunotherapy
Cancer systems biology, Single-cell quantitative biology, Computational modeling
Basement Membrane Structure and Metalloproteinases
Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Regeneration and Systemic Responses to Tissue Damage
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Molecular mechanisms controlling insulin signaling and fat synthesis.
Systems-biology approaches to cancer biology and virology.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
Neuronal Vulnerability: A Study of Cellular Mechanism
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Physiology & Biophysics
Identification of Novel Biomarkers for Inflammatory Myopathies
Transcriptional Regulation by NFKB
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
Molecular pathogenesis and genomic analysis of human cancers
Regulation and function of tyrosine phosphorylation in complex networks
Developmental Genetics, Evolution and Regeneration
Mechanisms of tissue/organ homeostasis and tumorigeensis
Nuclear Transport, Signaling, and Cancer
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Bioanalytical tools for inflammatory disease
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Genomics, Molecular Evolution, Algorithm Design and Analysis
Chromosome segregation and aneuploidy in meiosis and mitosis
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
computational biology & bioinformatics; high performance computing; epigenomics & chromatin; pediatric cancer; computational regulatory genomics; machine learning
Role of Glia in Neurological Illnesses and Cancer
Spatial Cell Biology. Neuronal Morphogenesis and Disease. Cancer Migration and Invasion.
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Molecular and bioelectric devices; tissue regeneration.
Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Genome instability in cancer and repeat expansion diseases
Investigating regeneration through genetics and single-cell analysis
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Cardiovascular Development and Cerebrovascular Pathologies
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Advanced machine learning; Theoretical and computational biophysic
Integrating high-throughput proteomic, chemical, genetic and computational tools for target identification and drug discovery in cancer biology
Early detection, cancer prevention, and tumor microenvironment
Single Cell Analysis