Research in Microbiology at UVA spans the fundamental molecular processes of viruses, bacteria, fungi, and parasites of major importance to human health.Many fundamental biological processes have been uncovered through the study of bacteria, viruses and eukaryotic unicellular microorganisms, and these studies have also revealed mechanisms by which infectious agents cause disease. Our students and faculty examine how microbes replicate, invade the host cell, colonize the host and interact with the immune system. To this end we use state-of-the-art experimental approaches drawn from the fields of molecular biology, biochemistry, genetics, structural biology, cell biology, physiology, cellular and sub-cellular imaging, genomics and bioinformatics.
The microbiology research community at UVA spans multiple basic science and clinical departments. It features numerous laboratories that are engaged in highly interactive and collaborative research, with many researchers sharing authorship on high-profile publications. Our research findings provide insights into basic biology and also provide foundations for translational applications, such as vaccine development and new therapeutic approaches for treating infections.
The robust educational opportunities available include specialized coursework, laboratory rotations, journal clubs, and weekly seminars highlighting the work of trainees as well as that of internationally renowned scientists.
Training in Microbiology at UVA equips our graduates to pursue diverse career options, including postdoctoral positions in academia, as well as jobs in government, the pharmaceutical and biotechnology industries, collegiate teaching, public policy, consulting and patent law.
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Regulation of gene expression during lymphocyte development
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Herpes Simplex Virus Infection of Neurons
The maternal and infant microbiome in childhood growth and immunity
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Macrophage effector functions in inflammation and immunotherapy
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Ebola, SARS-CoV-2, Influenza and Zika
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Super-resolution fluorescence imaging of bacterial cells
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Immune regulation for HCV infection and chronic liver inflammation
Immune response to infectious disease in the CNS
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Developmental regulation of planar cell polarity in the mammalian nervous system
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Pathogenicity of Francisella tularensis and vaccines
Structure-Function of Active Transporters
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Bioanalytical tools for inflammatory disease
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
Apoptotic cell clearance mechanisms in health and disease
Human Immunodeficiency; Virus Gene Expression
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
The immune response to common cold and allergens in health and disease.
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease