Microbiology

Research in Microbiology Research in Microbiology at UVA spans the fundamental molecular processes of viruses, bacteria, fungi, and parasites of major importance to human health.Many fundamental biological processes have been uncovered through the study of bacteria, viruses and eukaryotic unicellular microorganisms, and these studies have also revealed mechanisms by which infectious agents cause disease. Our students and faculty examine how microbes replicate, invade the host cell, colonize the host and interact with the immune system.  To this end we use state-of-the-art experimental approaches drawn from the fields of molecular biology, biochemistry, genetics, structural biology, cell biology, physiology, cellular and sub-cellular imaging, genomics and bioinformatics.

The microbiology research community at UVA spans multiple basic science and clinical departments.  It features numerous laboratories that are engaged in highly interactive and collaborative research, with many researchers sharing authorship on high-profile publications.  Our research findings provide insights into basic biology and also provide foundations for translational applications, such as vaccine development and new therapeutic approaches for treating infections.

The robust educational opportunities available include specialized coursework, laboratory rotations, journal clubs, and weekly seminars highlighting the work of trainees as well as that of internationally renowned scientists.

Training in Microbiology at UVA equips our graduates to pursue diverse career options, including postdoctoral positions in academia, as well as jobs in government, the pharmaceutical and biotechnology industries, collegiate teaching, public policy, consulting and patent law.

Faculty
  • Agaisse, Hervé

    Genetic approaches, cellular and molecular biology of intracellular pathogen infection

  • Ambati, Jayakrishna

    Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness

  • Bender, Timothy P.

    Regulation of gene expression during lymphocyte development

  • Brown, Michael G.

    Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation

  • Casanova, James E.

    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.

  • Cliffe, Anna

    Herpes Simplex Virus Infection of Neurons

  • Cowardin, Carrie A.

    The maternal and infant microbiome in childhood growth and immunity

  • Desai, Bimal N.

    Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis

  • Elliott, Michael R.

    Macrophage effector functions in inflammation and immunotherapy

  • Engel, Daniel A.

    Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Ebola, SARS-CoV-2, Influenza and Zika

  • Erickson, Loren D.

    Immune mechanisms of pathogenic antibody production in allergy and autoimmunity

  • Ewald, Sarah

    Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics

  • Gahlmann, Andreas

    Super-resolution fluorescence imaging of bacterial cells

  • Guler, Jennifer

    Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum

  • Hahn, Young S.

    Immune regulation for HCV infection and chronic liver inflammation

  • Harris, Tajie H.

    Immune response to infectious disease in the CNS

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Lu, Xiaowei

    Developmental regulation of planar cell polarity in the mammalian nervous system

  • Lukens, John R.

    Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders

  • Mann, Barbara J.

    Pathogenicity of Francisella tularensis and vaccines

  • Nakamoto, Robert K.

    Structure-Function of Active Transporters

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Pompano, Rebecca

    Bioanalytical tools for inflammatory disease

  • Pornillos, Owen

    Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system

  • Ramakrishnan, Girija

    Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis

  • Ravichandran, Kodi S.

    Apoptotic cell clearance mechanisms in health and disease

  • Rekosh, David M.

    Human Immunodeficiency; Virus Gene Expression

  • Rutkowski, Melanie

    Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis

  • Tamm, Lukas K.

    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

  • Vande Pol, Scott B.

    How Viruses, Particularly Papillomaviruses, Can Cause Cancer

  • White, Judith M.

    Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics

  • Woodfolk, Judith A.

    The immune response to common cold and allergens in health and disease.

  • Zeichner, Steven L.

    Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.

  • Zimring, James C

    Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease