Physiology

Render in labAn interdisciplinary approach employing advanced methods of molecular biology and structural biophysics is the hallmark of modern scientific research, whether fundamental, clinical or translational. Our research-intensive program aims to promote, at all levels, the understanding of the function of living systems while training students to identify significant biological problems and use the most advanced and modern methods for solving them. The emphasis of our department and expertise in molecular physiology and biophysics provide a unique environment for interdisciplinary training of PhD trainees.

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Program Faculty

  • Ai, Huiwang

    Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics

  • Bushweller, John H.

    Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins

  • Derewenda, Zygmunt S.

    Structure-function relationships in proteins

  • French, Brent A.

    Novel Therapies for Treating and Preventing Ischemic Heart Disease

  • Holmes, Jeffrey W.

    Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.

  • Isakson, Brant

    Translating our discoveries in the microcirculation to tangible benefits in patients.

  • Kasson, Peter M.

    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.

  • Kelly, Kimberly

    Advancement in the design of imaging agents; molecular imaging and radiological sciences.

  • Kramer, Christopher M.

    Cardiac magnetic resonance imaging, myocardial disease, atherosclerotic plaque imaging, peripheral arterial disease, hypertrophic cardiomyopathy

  • Laubach, Victor E.

    Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.

  • McNamara, Coleen A.

    Atherosclerosis, Obesity, Diabetes

  • Minor, Wladek

    Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific
    Reproducibility

  • Nakamoto, Robert K.

    Structure-Function of Active Transporters

  • Owens, Gary K.

    Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Peirce-Cottler, Shayn M.

    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies

  • Pornillos, Owen

    Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system

  • Saucerman, Jeffrey J.

    Roles of complex signaling networks involved in the regulation of cardiovascular function and disease

  • Somlyo, Avril V.

    Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.

  • Sonkusare, Swapnil

    Microcirculation, vascular ion channels, calcium signaling mechanisms, endothelial cells, hypertension

  • Tamm, Lukas K.

    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

  • Wiener, Michael C.

    Structure/function of integral membrane proteins; structural biophysics; enzymology and virology of ZMPSTE24; sparse-constraint structure determination; technology development

  • Wolf, Matthew J

    Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.

  • Yan, Zhen

    Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity

  • Yeager, Mark

    Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus

  • Zimmer, Jochen

    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.