Research in Molecular Biology at UVA employs a variety of techniques to identify and characterize molecular interactions and determine how such interactions are regulated.Regardless of whether a research lab focuses on biological problems at the organismal, cellular, biochemical, biophysical or structural level, the discipline of molecular biology likely plays an integral role. The techniques of molecular biology include manipulation of DNA (including cloning and PCR), gel electrophoresis, immunoprecipitation, and various types of hybridization techniques (including “blots”) to detect DNA, RNA or protein.
At the University of Virginia, graduate students in the majority of our research labs employ molecular biological approaches to address problems that span the full range of modern biological inquiry. We seek graduate students with a passionate interest in exploiting any and all avenues to discover answers to the most important biological problems.
Since molecular biology impacts virtually all aspects of biological research, training in this discipline helps provide our students with the foundation needed for successful careers in academia and industry.
The Ubiquitin System and Human Cancer
Identify and target key genomic and epigenomic drivers in cancer
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Molecular Mechanisms of Transcriptional Regulation
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Circuit mechanisms of sleep and epilepsy
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Regulation of gene expression during lymphocyte development
Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Signaling Pathways and Breast Cancer
Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
Epigenetic mechanisms involved in complex human disease
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Structure-function relationships in proteins
Host/pathogen Interaction - Chlamydia Infection
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer; Bioinformatics of cancer outcome
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Macrophage effector functions in inflammation and immunotherapy
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Ebola, SARS-CoV-2, Influenza and Zika
Innate immunity, chronic disease, host-parasite interactions, Toxoplasma gondii, proteomics
Systems Genetics of Skeletal Development and Maintenance
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Super-resolution fluorescence imaging of bacterial cells
The Structural Biology of HIV assembly
Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Molecular embryology--gene regulation in cells committed to specific developmental lineages
Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
Circadian entrainment for the treatment of metabolic and neurodegenerative diseases
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Neural control of blood pressure and respiration
Regeneration and Systemic Responses to Tissue Damage
Molecular mechanisms controlling insulin signaling and fat synthesis.
Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria
Systems-biology approaches to cancer biology and virology.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Cellular and molecular mechanisms of morphogenesis
Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Nanotechnologies for targeted drug delivery
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
The role of glia in the development, maintenance and regeneration of the nervous system
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Developmental regulation of planar cell polarity in the mammalian nervous system
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Molecular Mechanisms of Myotonic Muscular Dystrophy
Transcriptional Regulation by NFKB
The Cause and Consequence of Somatic Mosaicism in Neurons
Atherosclerosis, Obesity, Diabetes
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Regulation and function of tyrosine phosphorylation in complex networks
Obesity and Aging
Investigating the cell-biological foundations of development
Mechanisms of organ development and homeostasis and tumor development
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
Apoptotic cell clearance mechanisms in health and disease
Human Immunodeficiency; Virus Gene Expression
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.
Regulation of neural stem cell proliferation during development and adulthood
Tailored fit targeting approaches: Cancer Immunotherapy, Antibodies and conjugates
Transcriptional Silencing and Aging in Yeast
Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Genome instability in cancer and repeat expansion diseases
Cellular and molecular mechanisms of allergic disease in humans.
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus
Mammalian kidney development
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
Neural Circuits in Healthy and Diseased Brains
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.
Early detection, cancer prevention, and tumor microenvironment