Molecular Biology

Mol Bio ImageResearch in Molecular Biology at UVA employs a variety of techniques to identify and characterize molecular interactions and determine how such interactions are regulated.Regardless of whether a research lab focuses on biological problems at the organismal, cellular, biochemical, biophysical or structural level, the discipline of molecular biology likely plays an integral role.  The techniques of molecular biology include manipulation of DNA (including cloning and PCR), gel electrophoresis, immunoprecipitation, and various types of hybridization techniques (including “blots”) to detect DNA, RNA or protein.

At the University of Virginia, graduate students in the majority of our research labs employ molecular biological approaches to address problems that span the full range of modern biological inquiry. We seek graduate students with a passionate interest in exploiting any and all avenues to discover answers to the most important biological problems.

Since molecular biology impacts virtually all aspects of biological research, training in this discipline helps provide our students with the foundation needed for successful careers in academia and industry.

Faculty
  • Abbas, Tarek A.

    The Ubiquitin System and Human Cancer

  • Adli, Mazhar

    Identify and target key genomic and epigenomic drivers in cancer

  • Agaisse, Hervé

    Genetic approaches, cellular and molecular biology of intracellular pathogen infection

  • Ai, Huiwang

    Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics

  • Auble, David T.

    Molecular Mechanisms of Transcriptional Regulation

  • Barrett, Paula Q.

    Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.

  • Beenhakker, Mark P.

    Circuit mechanisms of sleep and epilepsy

  • Bekiranov, Stefan

    Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks

  • Bender, Timothy P.

    Regulation of gene expression during lymphocyte development

  • Bhatnagar, Sanchita

    Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome

  • Bland, Michelle

    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism

  • Bochkis, Irina

    Epigenetic and genetic mechanisms underlying metabolic disease

  • Bouton, Amy H.

    Signaling Pathways and Breast Cancer

  • Caliari, Steven

    Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment

  • Connelly, Jessica J.

    Epigenetic mechanisms involved in complex human disease

  • Cross, Janet V.

    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention

  • Deppmann, Christopher

    Elucidating and Understanding the Mechanisms Underlying Nervous System Development

  • Derewenda, Zygmunt S.

    Structure-function relationships in proteins

  • Derré, Isabelle

    Host/pathogen Interaction – Chlamydia Infection

  • Desai, Bimal N.

    Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis

  • Dutta, Anindya

    Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer

  • Dwyer, Noelle

    Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance

  • Engel, Daniel A.

    Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

  • Ewald, Sarah

    Innate immunity, chronic disease, host-parasite interactions

  • Farber, Charles R.

    Systems Genetics of Skeletal Development and Maintenance

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Gahlmann, Andreas

    Super-resolution fluorescence imaging of bacterial cells

  • Ganser-Pornillos, Barbie

    The Structural Biology of HIV assembly

  • Garrett-Bakelman, Francine

    Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression

  • Gelfand, Bradley

    Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.

  • Gioeli, Daniel

    Signal transduction in cancer cells

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Grainger, Robert M.

    Molecular embryology–gene regulation in cells committed to specific developmental lineages

  • Grant, Patrick A.

    Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer

  • Guertin, Michael

    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology

  • Guler, Ali D.

    Signal Processing by the Central Nervous System

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Guyenet, Patrice G.

    Neural control of blood pressure and respiration

  • Halme, Adrian J.

    Regeneration and Systemic Responses to Tissue Damage

  • Harris, Thurl E

    Molecular mechanisms controlling insulin signaling and fat synthesis.

  • Hockensmith, Joel W.

    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria

  • Janes, Kevin A.

    Systems-biology approaches to cancer biology and virology.

  • Jiang, Hao

    Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

  • Kashatus, David F

    The Role of Mitochondrial Fusion and Fission in Tumorigenesis.

  • Kasson, Peter M.

    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.

  • Keller, Raymond E.

    Cellular and molecular mechanisms of morphogenesis

  • Keller, Susanna R.

    Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Kipnis, Jonathan

    Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration

  • Kucenas, Sarah C.

    The role of glia in the development, maintenance and regeneration of the nervous system

  • Laubach, Victor E.

    Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.

  • Leitinger, Norbert

    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Loughran, Jr., Thomas P

    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)

  • Lu, Xiaowei

    Developmental regulation of planar cell polarity in the mammalian nervous
    system

  • Lukens, John R.

    Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders

  • Mahadevan, Mani S.

    Molecular Mechanisms of Myotonic Muscular Dystrophy

  • Mayo, Marty W.

    Transcriptional Regulation by NFKB

  • McConnell, Michael J

    The Cause and Consequence of Somatic Mosaicism in Neurons

  • McNamara, Coleen A.

    Atherosclerosis, Obesity, Diabetes

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • Mohi, Golam

    Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • O’Rourke, Eyleen Jorgelina

    Obesity and Aging

  • Park, Kwon-Sik

    Mechanisms of organ development and homeostasis and tumor development

  • Peirce-Cottler, Shayn M.

    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies

  • Pemberton, Lucy F.

    Nuclear Transport in Chromatin Assembly and Transcriptional Regulation

  • Pornillos, Owen

    Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system

  • Ramakrishnan, Girija

    Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis

  • Ravichandran, Kodi S.

    Apoptotic cell clearance mechanisms in health and disease

  • Rekosh, David M.

    Human Immunodeficiency; Virus Gene Expression

  • Schulman, Ira G.

    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

  • Shi, Weibin

    Cellular and genetic determinants of atherosclerosis and restenosis.

  • Shin, Jung-Bum

    Auditory Neurobiology

  • Siegrist, Sarah

    Regulation of neural stem cell proliferation during development and adulthood

  • Singh, Jogender Tushir

    Tailored fit targeting approaches: Cancer Immunotherapy, Antibodies and conjugates

  • Smith, Jeffrey S.

    Transcriptional Silencing and Aging in Yeast

  • Smith, M. Mitchell

    Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle

  • Stukenberg, P. Todd

    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

  • Tamm, Lukas K.

    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

  • Thisse, Christine I.

    Molecular Mechanisms of Early Vertebrate Development and Morphogenesis.
    Application to Stem Cell Biology and Regenerative Medicine

  • Vande Pol, Scott B.

    How Viruses, Particularly Papillomaviruses, Can Cause Cancer

  • Wang, Yuh-Hwa

    Genome instability in cancer and repeat expansion diseases

  • Woodfolk, Judith A.

    Cellular and molecular mechanisms of allergic disease in humans.

  • Wotton, David

    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

  • Yeager, Mark

    Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus

  • Yu, Jing

    Mammalian kidney development

  • Zeichner, Steven L.

    Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.

  • Zhu, J. Julius

    Neural Circuits in Healthy and Diseased Brains

  • Zimmer, Jochen

    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.

  • Zong, Hui

    Early detection, cancer prevention, and tumor microenvironment