Molecular Pharmacology

Aorta AntagonistResearch in Molecular Pharmacology at UVA focuses on mechanisms by which hormones, neurotransmitters, autacoids, synthetic chemical agents, and toxins modulate biological processes.It draws on all traditional basic science fields to provide a synthetic understanding of how drug targets regulate normal physiological mechanisms and contribute to pathophysiology of disease.  Thus, pharmacologists work to identify drug targets with the ultimate goal of intervening — with rational and effective drug therapy — in signaling cascades and metabolic pathways that have gone awry.  Such intervention requires understanding of the major organismal control systems and identification of defects in these systems that occur with disease.

The Pharmacological Sciences Training Program at the University of Virginia encompasses the breadth of this discipline and provides students with a solid foundation for lifelong careers in pharmacology.  The diverse expertise of the pharmacology faculty provides training opportunities that encompass molecular and cellular biology in the context of whole animal physiology, drug discovery and translational medicine. Students are supported by the Pharmacological Sciences Training Grant, now in its 39th year.

 

Faculty
  • Ai, Huiwang

    Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics

  • Barrett, Paula Q.

    Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.

  • Bayliss, Douglas A.

    Mechanisms of neuromodulation in central neurons

  • Beenhakker, Mark P.

    Circuit mechanisms of sleep and epilepsy

  • Bland, Michelle

    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism

  • Bochkis, Irina

    Epigenetic and genetic mechanisms underlying metabolic disease

  • Bushweller, John H.

    Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins

  • Civelek, Mete

    Systems Genetics Approaches to Understand Cardiometabolic Traits

  • Creutz, Carl E.

    Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis

  • Desai, Bimal N.

    Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis

  • Engel, Daniel A.

    Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • French, Brent A.

    Novel Therapies for Treating and Preventing Ischemic Heart Disease

  • Guertin, Michael

    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Guyenet, Patrice G.

    Neural control of blood pressure and respiration

  • Harris, Thurl E

    Molecular mechanisms controlling insulin signaling and fat synthesis.

  • Hockensmith, Joel W.

    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria

  • Hsu, Ku-Lung

    Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry

  • Isakson, Brant

    Translating our discoveries in the microcirculation to tangible benefits in patients.

  • Kadl, Alexandra

    Lung injury and repair, sepsis

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Kinsey, Gilbert

    Acute Kidney Injury, Regulatory T Cells, Innate Immune Response

  • Laurie, Gordon W.

    Role of Prosecretory Mitogen ‘Lacritin’ in Epithelial Homeostasis, Secretion and Innate Defense

  • Lazo, John S.

    The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases

  • Leitinger, Norbert

    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

  • Lynch, Kevin R.

    Chemical biology of sphingosine 1-phosphate

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • Mohi, Golam

    Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.

  • Nakamoto, Robert K.

    Structure-Function of Active Transporters

  • Patel, Manoj

    Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons

  • Perez-Reyes, Edward

    Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.

  • Pompano, Rebecca

    Bioanalytical tools for inflammatory disease

  • Schulman, Ira G.

    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery

  • Scott, Michael M.

    Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior

  • Venton, B. Jill

    Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents

  • Yan, Zhen

    Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity

  • Zhu, J. Julius

    Neural Circuits in Healthy and Diseased Brains