Research in Molecular Pharmacology at UVA focuses on mechanisms by which hormones, neurotransmitters, autacoids, synthetic chemical agents, and toxins modulate biological processes.It draws on all traditional basic science fields to provide a synthetic understanding of how drug targets regulate normal physiological mechanisms and contribute to pathophysiology of disease. Thus, pharmacologists work to identify drug targets with the ultimate goal of intervening — with rational and effective drug therapy — in signaling cascades and metabolic pathways that have gone awry. Such intervention requires understanding of the major organismal control systems and identification of defects in these systems that occur with disease.
The Pharmacological Sciences Training Program at the University of Virginia encompasses the breadth of this discipline and provides students with a solid foundation for lifelong careers in pharmacology. The diverse expertise of the pharmacology faculty provides training opportunities that encompass molecular and cellular biology in the context of whole animal physiology, drug discovery and translational medicine. Students are supported by the Pharmacological Sciences Training Grant, now in its 39th year.
Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Systems Genetics Approaches to Understand Cardiometabolic Traits
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Ebola, SARS-CoV-2, Influenza and Zika
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Molecular mechanisms controlling insulin signaling and fat synthesis.
Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria
Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
Translating our discoveries in the microcirculation to tangible benefits in patients.
Lung injury and repair, sepsis
Nanotechnologies for targeted drug delivery
Acute Kidney Injury, Regulatory T Cells, Innate Immune Response
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Chemical biology of sphingosine 1-phosphate
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Structure-Function of Active Transporters
Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Bioanalytical tools for inflammatory disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
Neural Circuits in Healthy and Diseased Brains