Physiological Basis of Human Disease
Research in Physiological Basis of Human Disease at UVA aims to elucidate the cellular and molecular mechanisms of basic biological phenomena and to understand the pathological alterations of these processes that result in disease.
Our research seeks to integrate insights gained at the molecular and cellular levels into the broader framework of organ function, with the goal of understanding the function of living systems at all levels. This understanding is based on knowledge of atomic and molecular structure and function. Thus a modern molecular physiologist may investigate the function of the heart by cloning a membrane channel or transport protein, expressing it and studying its kinetics through patch clamping in a model cell system, while exploring the relationship between molecular structure and function through crystallography and spectroscopy.
We emphasize interdisciplinary systems approaches. Consequently, members of our program are associated with many departments in basic sciences, clinical medicine, and in particular the Robert Berne Cardiovascular Research Center and Biomedical Engineering.
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Molecular Biosensors; Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
Innate immunity, Cell clearance, Inflammatory and autoimmune disease
Mechanisms of neuromodulation in central neurons
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Molecular Physiology and Biological Physics
Hematology and Oncology, Cell Biology, Lipid Signaling, Cancer Cell Signaling, and RNA Biology
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
Structure-function relationships in proteins
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging
Systems Genetics of Skeletal Development and Maintenance
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Super-resolution fluorescence imaging of bacterial cells
Pathophysiological mechanisms and impact of cell state transitions
Molecular mechanisms controlling insulin signaling and fat synthesis.
Translating our discoveries in the microcirculation to tangible benefits in patients.
The Pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and other dementia-related disorders.
Seizures, neuronal excitability and plasticity
RNA regulatory networks and RNA binding proteins during cardiovascular development and in cardiovascular disease
Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation to identifying therapeutic targets.
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Composition, Biophysics and Physiology of Cellular Membranes
Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility
Understanding the neural code underlying motivated behaviors like feeding, drinking, and social interaction, with a focus on how malfunction in associated brain areas are involved in diseases like addiction and eating disorders
Obesity and Aging
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Investigating the cell-biological foundations of development
Understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13) and temporal lobe epilepsy. My lab uses a number of experimental techniques including patch clamp electrophysiology and in vivo seizure monitor
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Delineate the physiological importance and structure-function relationship of ER-associated degradation in humans.
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.
Identify the calcium signaling abnormalities that lead to vascular dysfunction and blood pressure elevation in cardiovascular disorders
Role of Glia in Neurological Illnesses and Cancer
Spatial Cell Biology. Neuronal Morphogenesis and Disease. Cancer Migration and Invasion.
Role of endoplasmic reticulum-associated protein degradation in health and disease
Regulation of cell-surface stability and intracellular trafficking of membrane proteins in epithelial cells
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery
Toward better understanding of and innovative therapies for peripheral vascular diseases
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.