Genetics
About
Research in Genetics at UVA seeks to understand how genetic information is encoded, inherited, decoded, and differentially regulated to produce the vast diversity observed in biology.While the genome revolution has generated vast amounts of data on sequences and expression, genetics bridges the gap between structure (sequence) and biological function. Fueled by powerful technologies for determining DNA sequences and surveying gene expression, geneticists seek to determine the function of every gene in the genome. Functional data from genetic screens holds great promise for medicine, agriculture, pharmaceuticals and many other aspects of our lives.
The genetics program at the University of Virginia provides training opportunities with numerous faculty members across grounds. It encompasses the full spectrum of genetic research, from genes to genomes to populations, in a diverse range of biological systems. We train graduates for careers in genetics at academic institutions, biotechnology and pharmaceutical companies, private research institutes, and government research laboratories.
Faculty
Abbas, Tarek A.
The Ubiquitin System and Human Cancer
Bajikar, Sameer Subhash
Systems biology approaches to study gene dosage in neurodevelopment and neurodevelopmental disorders
Bielinsky, Anja Katrin
Genome instability syndromes in cancer and immune deficiencies
Bland, Michelle
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Brown, Michael G.
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Chen, Wei-Min
Statistical genetics and genomics.
Civelek, Mete
Systems Genetics Approaches to Understand Cardiometabolic Traits
Connelly, Jessica J.
Epigenetic mechanisms involved in complex human disease
Coutinho-Budd, Jaeda
Neuron-glia and glial-glial interactions
Dremel, Sarah
Herpesvirus gene expression & RNA biology
Dwyer, Noelle
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Farber, Charles R.
Systems Genetics of Skeletal Development and Maintenance
Garcia-Blanco, Mariano A.
RNA-protein interactions in antiviral immunity and autoimmune diseases.
Grainger, Robert M.
Molecular embryology--gene regulation in cells committed to specific developmental lineages
Halme, Adrian J.
Regeneration and Systemic Responses to Tissue Damage
Hirschi, Karen Kemper
Understanding Cellular and Molecular Mechanisms Leading to Blood Vessel Formation
Kaya, Alaattin
Metabolic and Genetic Regulation of Aging, Redox Biology, DNA Repair, Comparative and Functional Genomics, Stress Resistance, Drug Discovery, Evolutionary Biology, Synthetic and Systems Biology for Evolutionary Engineering, Adaptive Evolution, Mitochondrial Signaling, Neurodegenerative Diseases
Kozminski, Keith G.
Regulation of Polarized Morphogenesis
Kucenas, Sarah C
The role of glia in the development, maintenance and regeneration of the nervous system
Kulkarni, Saurabh
Precision medicine, translational science, regeneration, organoids, high resolution imaging, computational modeling
Liu, Wenpeng
Genetic and Epigenetic stability in human cancer
Mahadevan, Mani S.
Molecular Mechanisms of Myotonic Muscular Dystrophy
Manichaikul, Ani W.
Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis
Martin, Timothy D
Identifying tumor selective drug targets, Understanding the genetic drivers of tumor immune evasion
Miller, Clint L.
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Mohi, Golam
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
O’Rourke, Eyleen Jorgelina
Obesity and Aging
Pani, Ariel
Investigating the cell-biological foundations of development
Parichy, David
Developmental Genetics, Evolution and Regeneration
Park, Kwon
Mechanisms of tissue/organ homeostasis and tumorigeensis
Patel, Manoj
Understanding the cellular mechanisms by which seizures are initiated in SCN8A epileptic encephalopathy (DEE13) and temporal lobe epilepsy. My lab uses a number of experimental techniques including patch clamp electrophysiology and in vivo seizure monitor
Pemberton, Lucy F.
Director of Graduate Studies for Microbiology, Immunology and Cancer Biology
Platig, John
Gene regulatory networks, Systems genetics, Multi-omic data integration, Network science
Ratan, Aakrosh
Genomics, Molecular Evolution, Algorithm Design and Analysis
Rekosh, David M.
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Rich, Stephen S.
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Sheynkman, Gloria M.
Proteoform Systems Biology: proteogenomic approaches to uncover the role of proteomic variation in human disease
Shi, Weibin
Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.
Siegrist, Sarah
Regulation of neural stem cell proliferation during development and adulthood
Smith, Jeffrey S.
Transcriptional Silencing and Aging in Yeast
Stukenberg, P. Todd
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Sutherland, Ann E.
Cell behavior and morphogenesis during early mouse development.
Trinh, Bon Q
Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases
Wang, Yuh-Hwa
Genome instability in cancer and repeat expansion diseases
Wolf, Matthew J
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
Wotton, David
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Wythe, Joshua D
Cardiovascular Development and Cerebrovascular Pathologies
Zang, Chongzhi
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Advanced machine learning; Theoretical and computational biophysics
Zhou, Anny Xiaobo
Genetics, Functional Genomics, Epigenetics, Lung repair/regeneration, Metabolic regulation, Alveolar stem cells, Chromatin interaction, Innate immune response, Live-cell imaging
Zimring, James C
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
Zong, Hui
Early detection, cancer prevention, and tumor microenvironment