Genetics

Research in Genetics, zoomed in photo of gene sequence  Research in Genetics at UVA seeks to understand how genetic information is encoded, inherited, decoded, and differentially regulated to produce the vast diversity observed in biology.While the genome revolution has generated vast amounts of data on sequences and expression, genetics bridges the gap between structure (sequence) and biological function.  Fueled by powerful technologies for determining DNA sequences and surveying gene expression, geneticists seek to determine the function of every gene in the genome.  Functional data from genetic screens holds great promise for medicine, agriculture, pharmaceuticals and many other aspects of our lives.

The genetics program at the University of Virginia provides training opportunities with numerous faculty members across grounds.  It encompasses the full spectrum of genetic research, from genes to genomes to populations, in a diverse range of biological systems. We train graduates for careers in genetics at academic institutions, biotechnology and pharmaceutical companies, private research institutes, and government research laboratories.

Faculty
  • Abbas, Tarek A.

    The Ubiquitin System and Human Cancer

  • Adler, Paul N.

    Planar signaling, polarity and morphogenesis.

  • Agaisse, Hervé

    Genetic approaches, cellular and molecular biology of intracellular pathogen infection

  • Auble, David T.

    Molecular Mechanisms of Transcriptional Regulation

  • Bender, Timothy P.

    Regulation of gene expression during lymphocyte development

  • Bland, Michelle

    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism

  • Bochkis, Irina

    Epigenetic and genetic mechanisms underlying metabolic disease

  • Brown, Michael G.

    Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation

  • Chen, Wei-Min

    Statistical genetics and genomics.

  • Civelek, Mete

    Systems Genetics Approaches to Understand Cardiometabolic Traits

  • Connelly, Jessica J.

    Epigenetic mechanisms involved in complex human disease

  • Derré, Isabelle

    Host/pathogen Interaction – Chlamydia Infection

  • Dwyer, Noelle

    Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance

  • Farber, Charles R.

    Systems Genetics of Skeletal Development and Maintenance

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Grainger, Robert M.

    Molecular embryology–gene regulation in cells committed to specific developmental lineages

  • Grant, Patrick A.

    Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer

  • Guertin, Michael

    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology

  • Halme, Adrian J.

    Regeneration and Systemic Responses to Tissue Damage

  • Jiang, Hao

    Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

  • Kendall, Melissa M.

    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens

  • Kucenas, Sarah C.

    The role of glia in the development, maintenance and regeneration of the nervous system

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Lu, Xiaowei

    Developmental regulation of planar cell polarity in the mammalian nervous
    system

  • Mahadevan, Mani S.

    Molecular Mechanisms of Myotonic Muscular Dystrophy

  • Manichaikul, Ani W.

    Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis

  • McConnell, Michael J

    The Cause and Consequence of Somatic Mosaicism in Neurons

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • Mohi, Golam

    Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.

  • O’Rourke, Eyleen Jorgelina

    Obesity and Aging

  • Parichy, David

    Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates

  • Park, Kwon-Sik

    Mechanisms of organ development and homeostasis and tumor development

  • Pemberton, Lucy F.

    Nuclear Transport in Chromatin Assembly and Transcriptional Regulation

  • Ratan, Aakrosh

    Genomics, Molecular Evolution, Algorithm Design and Analysis

  • Rekosh, David M.

    Human Immunodeficiency; Virus Gene Expression

  • Rich, Stephen S.

    Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis

  • Shi, Weibin

    Cellular and genetic determinants of atherosclerosis and restenosis.

  • Siegrist, Sarah

    Regulation of neural stem cell proliferation during development and adulthood

  • Smith, Jeffrey S.

    Transcriptional Silencing and Aging in Yeast

  • Smith, M. Mitchell

    Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle

  • Stukenberg, P. Todd

    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

  • Thisse, Christine I.

    Molecular Mechanisms of Early Vertebrate Development and Morphogenesis.
    Application to Stem Cell Biology and Regenerative Medicine

  • Wang, Yuh-Hwa

    Genome instability in cancer and repeat expansion diseases

  • Wolf, Matthew J

    Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.

  • Wotton, David

    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

  • Yu, Jing

    Mammalian kidney development

  • Zang, Chongzhi

    Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics

  • Zong, Hui

    Early detection, cancer prevention, and tumor microenvironment