Research in Genetics at UVA seeks to understand how genetic information is encoded, inherited, decoded, and differentially regulated to produce the vast diversity observed in biology.While the genome revolution has generated vast amounts of data on sequences and expression, genetics bridges the gap between structure (sequence) and biological function. Fueled by powerful technologies for determining DNA sequences and surveying gene expression, geneticists seek to determine the function of every gene in the genome. Functional data from genetic screens holds great promise for medicine, agriculture, pharmaceuticals and many other aspects of our lives.
The genetics program at the University of Virginia provides training opportunities with numerous faculty members across grounds. It encompasses the full spectrum of genetic research, from genes to genomes to populations, in a diverse range of biological systems. We train graduates for careers in genetics at academic institutions, biotechnology and pharmaceutical companies, private research institutes, and government research laboratories.
The Ubiquitin System and Human Cancer
Planar signaling, polarity and morphogenesis.
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Molecular Mechanisms of Transcriptional Regulation
Regulation of gene expression during lymphocyte development
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Statistical genetics and genomics.
Systems Genetics Approaches to Understand Cardiometabolic Traits
Epigenetic mechanisms involved in complex human disease
Host/pathogen Interaction - Chlamydia Infection
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Systems Genetics of Skeletal Development and Maintenance
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Molecular embryology--gene regulation in cells committed to specific developmental lineages
Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
Regeneration and Systemic Responses to Tissue Damage
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
The role of glia in the development, maintenance and regeneration of the nervous system
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Developmental regulation of planar cell polarity in the mammalian nervous system
Molecular Mechanisms of Myotonic Muscular Dystrophy
Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis
The Cause and Consequence of Somatic Mosaicism in Neurons
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Obesity and Aging
Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates
Mechanisms of organ development and homeostasis and tumor development
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Genomics, Molecular Evolution, Algorithm Design and Analysis
Human Immunodeficiency; Virus Gene Expression
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.
Regulation of neural stem cell proliferation during development and adulthood
Transcriptional Silencing and Aging in Yeast
Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
Genome instability in cancer and repeat expansion diseases
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Mammalian kidney development
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics
Early detection, cancer prevention, and tumor microenvironment