Genetics
Research in Genetics at UVA seeks to understand how genetic information is encoded, inherited, decoded, and differentially regulated to produce the vast diversity observed in biology.While the genome revolution has generated vast amounts of data on sequences and expression, genetics bridges the gap between structure (sequence) and biological function. Fueled by powerful technologies for determining DNA sequences and surveying gene expression, geneticists seek to determine the function of every gene in the genome. Functional data from genetic screens holds great promise for medicine, agriculture, pharmaceuticals and many other aspects of our lives.
The genetics program at the University of Virginia provides training opportunities with numerous faculty members across grounds. It encompasses the full spectrum of genetic research, from genes to genomes to populations, in a diverse range of biological systems. We train graduates for careers in genetics at academic institutions, biotechnology and pharmaceutical companies, private research institutes, and government research laboratories.
Faculty
Abbas, Tarek A.
The Ubiquitin System and Human Cancer
Agaisse, Hervé
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Auble, David T.
Molecular Mechanisms of Transcriptional Regulation
Bland, Michelle
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
Bochkis, Irina
Epigenetic and genetic mechanisms underlying metabolic disease
Brown, Michael G.
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Chen, Wei-Min
Statistical genetics and genomics.
Civelek, Mete
Systems Genetics Approaches to Understand Cardiometabolic Traits
Connelly, Jessica J.
Epigenetic mechanisms involved in complex human disease
Coutinho-Budd, Jaeda
Neuron-glia and glial-glial interactions
Derré, Isabelle
Host/pathogen Interaction - Chlamydia Infection
Dwyer, Noelle
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Farber, Charles R.
Systems Genetics of Skeletal Development and Maintenance
Felder, Robin A.
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Grainger, Robert M.
Molecular embryology--gene regulation in cells committed to specific developmental lineages
Guertin, Michael
Halme, Adrian J.
Regeneration and Systemic Responses to Tissue Damage
Jiang, Hao
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
Kendall, Melissa M.
Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
Kucenas, Sarah C.
The role of glia in the development, maintenance and regeneration of the nervous system
Li, Hui
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Lu, Xiaowei
Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure
Mahadevan, Mani S.
Molecular Mechanisms of Myotonic Muscular Dystrophy
Manichaikul, Ani W.
Statistical Genetics, Genetic Epidemiology, Biostatistics, Network analysis
Miller, Clint L.
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Mohi, Golam
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
O’Rourke, Eyleen Jorgelina
Obesity and Aging
Pani, Ariel
Investigating the cell-biological foundations of development
Parichy, David
Developmental Genetics, Evolution and Regeneration
Park, Kwon-Sik
Mechanisms of organ homeostasis and tumor development
Pemberton, Lucy F.
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Ratan, Aakrosh
Genomics, Molecular Evolution, Algorithm Design and Analysis
Rekosh, David M.
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Rich, Stephen S.
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
Shi, Weibin
Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.
Siegrist, Sarah
Regulation of neural stem cell proliferation during development and adulthood
Smith, Jeffrey S.
Transcriptional Silencing and Aging in Yeast
Stukenberg, P. Todd
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Wang, Yuh-Hwa
Genome instability in cancer and repeat expansion diseases
Wolf, Matthew J
Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
Wotton, David
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Zang, Chongzhi
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Advanced machine learning; Theoretical and computational biophysic
Zong, Hui
Early detection, cancer prevention, and tumor microenvironment