Research in Experimental Pathology at UVA involves researchers across the institution who study the molecular and cellular basis of human disease. This work is facilitated by close interactions with clinical colleagues across the Health System who provide perspectives on challenges in patient care.This rigorous training program takes advantage of a unique environment created by a faculty composed of basic scientists, research and diagnostic pathologists, and physician colleagues in other clinical specialties.
Traditional laboratory-based research is complemented by first hand exposure to clinical approaches used in the diagnosis and treatment of human disease. Coursework is designed to complement laboratory research and highlights the interface between basic science and the challenges faced in clinical medicine. In addition, opportunities exist to observe patient care directly through clinical rotations that allow students to experience the complete arc from diagnosis through therapeutic decisions to surgical, radiological or medical interventions.
The curriculum is enriched by a disease-focused participatory journal club and a seminar series that explores the molecular basis of human disease. Students have ongoing access to the expertise of their clinical colleagues as well as laboratory and tissue specimens to facilitate their research projects.
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Matrix Biology and Engineering
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Pathways to enhance T cell function in tumors.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Systems Genetics Approaches to Understand Cardiometabolic Traits
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
The Role of Diabetes in Cognitive Decline
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Systems-biology approaches to cancer biology and virology.
Nanotechnologies for targeted drug delivery
Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Molecular Mechanisms of Myotonic Muscular Dystrophy
Identification of Novel Biomarkers for Inflammatory Myopathies
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions
Regulation and function of tyrosine phosphorylation in complex networks
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Bioanalytical tools for inflammatory disease
Role of Glia in Neurological Illnesses and Cancer
Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease