Experimental Pathology

 molecular basis of human diseaseResearch in Experimental Pathology at UVA involves researchers across the institution who study the molecular and cellular basis of human disease.  This work is facilitated by close interactions with clinical colleagues across the Health System who provide perspectives on challenges in patient care.This rigorous training program takes advantage of a unique environment created by a faculty composed of basic scientists, research and diagnostic pathologists, and physician colleagues in other clinical specialties.

Traditional laboratory-based research is complemented by first hand exposure to clinical approaches used in the diagnosis and treatment of human disease.  Coursework is designed to complement laboratory research and highlights the interface between basic science and the challenges faced in clinical medicine.  In addition, opportunities exist to observe patient care directly through clinical rotations that allow students to experience the complete arc from diagnosis through therapeutic decisions to surgical, radiological or medical interventions.

The curriculum is enriched by a disease-focused participatory journal club and a seminar series that explores the molecular basis of human disease.  Students have ongoing access to the expertise of their clinical colleagues as well as laboratory and tissue specimens to facilitate their research projects.

Faculty
  • Ambati, Jayakrishna

    Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness

  • Barker, Thomas H.

    Matrix Biology and Engineering

  • Bertram, Edward H.

    Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.

  • Bloom, George S.

    Pathogenic mechanisms in Alzheimer’s Disease and other neurodegenerative disorders

  • Bullock, Timothy N.

    Pathways to enhance T cell function in tumors.

  • Casanova, James E.

    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.

  • Civelek, Mete

    Systems Genetics Approaches to Understand Cardiometabolic Traits

  • Cross, Janet V.

    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Ferris, Heather

    The Role of Diabetes in Cognitive Decline

  • French, Brent A.

    Novel Therapies for Treating and Preventing Ischemic Heart Disease

  • Gelfand, Bradley

    Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.

  • Gioeli, Daniel

    Signal transduction in cancer cells

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Guler, Jennifer

    Cell Biology and Parasitology.

  • Janes, Kevin A.

    Systems-biology approaches to cancer biology and virology.

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Kipnis, Jonathan

    Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration

  • Landen, Charles

    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies

  • Lazzara, Matthew

    Cellular Engineering

  • Leitinger, Norbert

    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Luckey, Chance John

    Immune Memory

  • Lukens, John R.

    Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders

  • Mahadevan, Mani S.

    Molecular Mechanisms of Myotonic Muscular Dystrophy

  • Mandell, James W.

    Identification of Novel Biomarkers for Inflammatory Myopathies

  • Miller, Clint L.

    Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

  • Moore, Sean

    Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • Owens, Gary K.

    Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Pompano, Rebecca

    Bioanalytical tools for inflammatory disease

  • Tung, Kenneth S.

    Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens

  • Zimring, James C

    Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease