Experimental Pathology
About
Research in Experimental Pathology at UVA involves researchers across the institution who study the molecular and cellular basis of human disease. This work is facilitated by close interactions with clinical colleagues across the Health System who provide perspectives on challenges in patient care.This rigorous training program takes advantage of a unique environment created by a faculty composed of basic scientists, research and diagnostic pathologists, and physician colleagues in other clinical specialties.
Traditional laboratory-based research is complemented by first hand exposure to clinical approaches used in the diagnosis and treatment of human disease. Coursework is designed to complement laboratory research and highlights the interface between basic science and the challenges faced in clinical medicine. In addition, opportunities exist to observe patient care directly through clinical rotations that allow students to experience the complete arc from diagnosis through therapeutic decisions to surgical, radiological or medical interventions.
The curriculum is enriched by a disease-focused participatory journal club and a seminar series that explores the molecular basis of human disease. Students have ongoing access to the expertise of their clinical colleagues as well as laboratory and tissue specimens to facilitate their research projects.
Faculty
Ambati, Jayakrishna
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Barker, Thomas H.
Matrix Biology and Engineering
Bauer, Todd
Tumor cell migration, invasion, metastasis, growth factor signalling
Bloom, George S.
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Bullock, Timothy N.
Pathways to enhance T cell function in tumors.
Casanova, James E.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.Civelek, Mete
Systems Genetics Approaches to Understand Cardiometabolic Traits
Cross, Janet V.
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Ebrahim, Seham
Cytoskeletal architecture, dynamics and roles in cellular physiology and disease; High-resolution live cell and tissue imaging
Fallahi-Sichani, Mohammad
Cancer systems biology, Single-cell quantitative biology, Computational modeling
Felder, Robin A.
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Ferris, Heather
Brain metabolism, cognitive decline and Alzheimer's disease
French, Brent A.
Novel Therapies for Treating and Preventing Ischemic Heart Disease
Gelfand, Bradley
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Gioeli, Daniel
Signal transduction in cancer cells
Goldfarb, Adam N.
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Guler, Jennifer
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Janes, Kevin A.
Systems-biology approaches to cancer biology and virology.
Landen, Charles
Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
Lazzara, Matthew
Cellular Engineering
Leitinger, Norbert
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Li, Hui
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Luckey, Chance John
Immune Memory
Lukens, John R.
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Ma, Jianjie
Physiology & Biophysics
Mahadevan, Mani S.
Molecular Mechanisms of Myotonic Muscular Dystrophy
Mandell, James W.
Identification of Novel Biomarkers for Inflammatory Myopathies
Miller, Clint L.
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Mohi, Golam
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
Moore, Sean
Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions
Naegle, Kristen
Regulation and function of tyrosine phosphorylation in complex networks
Owens, Gary K.
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Papin, Jason A.
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Pompano, Rebecca
Bioanalytical tools for inflammatory disease
Sheybani, Natasha
Biomedical Engineering
Sontheimer, Harald
Role of Glia in Neurological Illnesses and Cancer
Syed, Sana
Understanding why a subset of children living in in low- and middle-income countries around the world develop growth and vaccine failure
Tao, Jianguo
Pathology
Trinh, Bon Q
Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases
Tsihlis, Nick
Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery
Ukhanov, Kirill Y
Pharmacology
Wang, Bowen
Toward better understanding of and innovative therapies for peripheral vascular diseases
Zimring, James C
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease