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Experimental Pathology

About

 molecular basis of human diseaseResearch in Experimental Pathology at UVA involves researchers across the institution who study the molecular and cellular basis of human disease.  This work is facilitated by close interactions with clinical colleagues across the Health System who provide perspectives on challenges in patient care.This rigorous training program takes advantage of a unique environment created by a faculty composed of basic scientists, research and diagnostic pathologists, and physician colleagues in other clinical specialties.

Traditional laboratory-based research is complemented by first hand exposure to clinical approaches used in the diagnosis and treatment of human disease.  Coursework is designed to complement laboratory research and highlights the interface between basic science and the challenges faced in clinical medicine.  In addition, opportunities exist to observe patient care directly through clinical rotations that allow students to experience the complete arc from diagnosis through therapeutic decisions to surgical, radiological or medical interventions.

The curriculum is enriched by a disease-focused participatory journal club and a seminar series that explores the molecular basis of human disease.  Students have ongoing access to the expertise of their clinical colleagues as well as laboratory and tissue specimens to facilitate their research projects.

Faculty

  • Ambati, Jayakrishna

    Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness

  • Anderson, Kristin

    Engineering cancer-killing T cells to overcome obstacles in solid tumors

  • Arandjelovic, Sanja

    Innate immunity, Cell clearance, Inflammatory and autoimmune disease

  • Barker, Thomas H.

    Matrix Biology and Engineering

  • Bauer, Todd

    Cancer metastasis, chemotherapy resistance, genetic and epigenetic regulation

  • Bloom, George S.

    Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders

  • Bullock, Timothy N.

    Pathways to enhance T cell function in tumors.

  • Casanova, James E.

    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.

  • Cheng, Lily S

    Surgery

  • Cross, Janet V.

    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention

  • Erickson, Loren D.

    Immune mechanisms of pathogenic antibody production in allergy and autoimmunity

  • Fallahi-Sichani, Mohammad

    Cancer systems biology, Single-cell quantitative biology, Computational modeling

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Ferris, Heather

    Brain metabolism, cognitive decline and Alzheimer's disease

  • Gioeli, Daniel

    Signal transduction in cancer cells

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Griffin, Donald Richieri

    Biomedical Engineering

  • Guo, Lian-Wang

    Vascular wall remodeling, intimal hyperplasia, stenosis, aneurysm, retinal degeneration.

  • Kapur, Jaideep

    Seizures, neuronal excitability and plasticity

  • Kuan, Alex

    Neuroscience

  • Landen, Charles

    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies

  • Lazzara, Matthew

    Cellular Engineering

  • Lee, Kevin S.

    Neuronal Vulnerability: A Study of Cellular Mechanism

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Liu, Xiaorong

    Developing novel neuroprotection strategies to preserve vision in glaucoma

  • Lu, Xiaowei

    Wnt/PCP signaling in inner ear development Mouse models for human deafness Wnt/PCP signaling in neural tube closure

  • Luckey, Chance John

    Immune Memory

  • Lynch, Wendy J.

    Behavioral Pharmacology, Sex Differences, Animal Models of Addiction

  • Mahadevan, Mani S.

    Molecular Mechanisms of Myotonic Muscular Dystrophy

  • Mandell, James W.

    Identification of Novel Biomarkers for Inflammatory Myopathies

  • Mauldin, Ileana Soto

    Pathology

  • Moore, Sean

    Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • Owens, Gary K.

    Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

  • Petri, William A.

    Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections

  • Pompano, Rebecca

    Bioanalytical tools for inflammatory disease

  • Sontheimer, Harald

    Role of Glia in Neurological Illnesses and Cancer

  • Sperling, Anne

    Immune Responses in asthma, pulmonary fibrosis, and lung injury.

  • Syed, Sana

    Understanding why a subset of children living in in low- and middle-income countries around the world develop growth and vaccine failure. Investigating the causes and progression of inflammatory enteropathies of the gastrointestinal lumen. Integrating data science-driven approaches with medicine to drive precision medicine.

  • Tao, Jianguo

    Pathology

  • Trinh, Bon Q

    Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases

  • Tsihlis, Nick

    Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery

  • Vande Pol, Scott B.

    How Viruses, Particularly Papillomaviruses, Can Cause Cancer

  • Wang, Bowen

    Toward better understanding of and innovative therapies for peripheral vascular diseases

  • Witt, Russell Gardner

    Unraveling the Role of Obesity, Diet, and Lifestyle Factors in Melanoma Progression and Treatment Efficacy