Cellular and Molecular Metabolism
Research in Cellular and Molecular Metabolism at UVA focuses on the study of all chemical reactions in an organism and how dysregulation of these processes contributes to disease. These processes are tightly regulated under normal conditions to maintain homeostasis and ensure appropriate energy intake and fuel utilization. Regulation includes second-to-second flux of allosteric metabolites, intermediate control via signaling intermediates such as calcium and phosphorylation, and long-term regulation by transcription.
Dysregulation of fundamental metabolic processes can impair glucose or lipid homeostasis, alter mitochondrial function, and disrupt cell signaling cascades, leading to chronic diseases such as obesity, diabetes, inflammation, and atherosclerosis.
The metabolism group at UVA actively investigates how and why these defects occur, with the ultimate goal of improving both preventative therapy and treatment. The diverse expertise of the metabolism group provides training opportunities that utilize molecular and cellular biology and genetic approaches in the context of whole animal physiology, drug discovery, and translational medicine.
Students in the metabolism group are supported by several institutional training grants including: Pharmacological Sciences Training Grant; Cell & Molecular Biology Training Grant; and Biotechnology Training Program.
Engineering cancer-killing T cells to overcome obstacles in solid tumors
Molecular mechanisms linking innate immune and insulin signaling to control cell growth and metabolism
Epigenetic and genetic mechanisms underlying metabolic disease
Pathways to enhance T cell function in tumors.
The Neurobiology of Energy Balance
Systems Genetics Approaches to Understand Cardiometabolic Traits
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
Brain metabolism, cognitive decline and Alzheimer's disease
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Circadian entrainment for the treatment of metabolic and neurodegenerative diseases
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Regeneration and Systemic Responses to Tissue Damage
Molecular mechanisms controlling insulin signaling and fat synthesis.
Translating our discoveries in the microcirculation to tangible benefits in patients.
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Obesity and Aging
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Developmental Genetics, Evolution and Regeneration
Bioanalytical tools for inflammatory disease
Delineate the physiological importance and structure-function relationship of ER-associated degradation in humans.
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism and inflammation, small molecule approaches to drug discovery
Regulation of neural stem cell proliferation during development and adulthood
Transcriptional Silencing and Aging in Yeast
Viral immunology, T cells, Macrophages, Tissue repair
Role of endoplasmic reticulum-associated protein degradation in health and disease
Clonal hematopoiesis: A new mechanism of cardiovascular disease
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling