Experimental Pathology

Four different kinds of cells magnifiedThe Molecular and Cellular Basis of Disease (MCBD) graduate program confers the PhD in Experimental Pathology.  The program is designed for students with a research interest in the mechanisms of human disease processes, with a particular emphasis on the skills necessary to perform translational research. In addition to basic laboratory skills, the program offers the opportunity for collaborative work with top-ranked and internationally recognized pathologists and other clinicians as part of PhD training. These experiences provide our trainees with an understanding of modern medical problems and a unique perspective on approaches to move research from bench to bedside.

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Program Faculty

  • Ambati, Jayakrishna

    Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness

  • Barker, Thomas H.

    Matrix Biology and Engineering

  • Bloom, George S.

    Pathogenic mechanisms in Alzheimer’s Disease and other neurodegenerative disorders

  • Braciale, Thomas J.

    T Lymphocyte Responses To Virus Infection

  • Brown, Michael G.

    Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation

  • Bullock, Timothy N.

    Pathways to enhance T cell function in tumors.

  • Caliari, Steven

    Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment

  • Christ, George

    Functional Genomics

  • Civelek, Mete

    Systems Genetics Approaches to Understand Cardiometabolic Traits

  • Cross, Janet V.

    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention

  • Dutta, Anindya

    Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer

  • Felder, Robin A.

    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

  • Ferris, Heather

    The Role of Diabetes in Cognitive Decline

  • Gaultier, Alban

    Exploring new therapeutics avenues to treat Multiple Sclerosis.

  • Gelfand, Bradley

    Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.

  • Gioeli, Daniel

    Signal transduction in cancer cells

  • Goldfarb, Adam N.

    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis

  • Janes, Kevin A.

    Systems-biology approaches to cancer biology and virology.

  • Kester, Mark

    Nanotechnologies for targeted drug delivery

  • Landen, Charles

    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies

  • Lazzara, Matthew

    Cellular Engineering

  • Li, Hui

    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

  • Loughran, Jr., Thomas P

    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)

  • Luckey, Chance John

    Immune Memory

  • Mahadevan, Mani S.

    Molecular Mechanisms of Myotonic Muscular Dystrophy

  • Mandell, James W.

    Identification of Novel Biomarkers for Inflammatory Myopathies

  • McNamara, Coleen A.

    Atherosclerosis, Obesity, Diabetes

  • Moore, Sean

    Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions

  • Moskaluk, Christopher A.

    Molecular pathogenesis and genomic analysis of human cancers

  • Naegle, Kristen

    Regulation and function of tyrosine phosphorylation in complex networks

  • Owens, Gary K.

    Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

  • Papin, Jason A.

    Systems biology, infectious disease, cancer, toxicology, metabolic engineering

  • Paschal, Bryce M.

    Nuclear Transport, Signaling, and Cancer

  • Peirce-Cottler, Shayn M.

    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies

  • Petri, William A.

    Immune mechanisms of defense against enteric (diarrheal) infections

  • Purow, Benjamin W.

    Novel therapeutic approaches to brain cancers and to other neurologic diseases

  • Tung, Kenneth S.

    Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens

  • Vande Pol, Scott B.

    How Viruses, Particularly Papillomaviruses, Can Cause Cancer

  • Venton, B. Jill

    Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents

  • Yates, Paul A.

    Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.