The Molecular and Cellular Basis of Disease (MCBD) graduate program confers the PhD in Experimental Pathology. The program is designed for students with a research interest in the mechanisms of human disease processes, with a particular emphasis on the skills necessary to perform translational research. In addition to basic laboratory skills, the program offers the opportunity for collaborative work with top-ranked and internationally recognized pathologists and other clinicians as part of PhD training. These experiences provide our trainees with an understanding of modern medical problems and a unique perspective on approaches to move research from bench to bedside. For more information, click here…
Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Matrix Biology and Engineering
Cancer metastasis, chemotherapy resistance, genetic and epigenetic regulation
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Molecular Physiology and Biological Physics
Engineering biomaterials as cellular microenvironments
Systems Genetics Approaches to Understand Cardiometabolic Traits
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Brain metabolism, cognitive decline and Alzheimer's disease
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
Signal transduction in cancer cells
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Systems-biology approaches to cancer biology and virology.
Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Physiology & Biophysics
Molecular Mechanisms of Myotonic Muscular Dystrophy
Identification of Novel Biomarkers for Inflammatory Myopathies
Immune System Regulation of Cardiometabolic Disease
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
Structure and Function of the GI Tract in the Context of Childhood Nutrition, Growth, Immunity, and Host-microbe Interactions
Molecular pathogenesis and genomic analysis of human cancers
Regulation and function of tyrosine phosphorylation in complex networks
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Nuclear Transport, Signaling, and Cancer
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Immune mechanisms of defense against COVID-19 and enteric (diarrheal) infections
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Understanding why a subset of children living in in low- and middle-income countries around the world develop growth and vaccine failure. Investigating the causes and progression of inflammatory enteropathies of the gastrointestinal lumen. Integrating data science-driven approaches with medicine to drive precision medicine.
Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases
How Viruses, Particularly Papillomaviruses, Can Cause Cancer
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Toward better understanding of and innovative therapies for peripheral vascular diseases
Unraveling the Role of Obesity, Diet, and Lifestyle Factors in Melanoma Progression and Treatment Efficacy
Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease