Center for Membrane and Cell Physiology

At UVA’s Center for Membrane and Cell Physiology, we strive to understand fundamental biological processes at the highest possible spatial and time resolution. Our ultimate goal is to use high-end imaging, structural, biophysical, and biological and chemical probe technologies to make impactful discoveries on understanding the causes, development and cures of diseases ranging from cardiovascular to cancer to neurological and infectious diseases.

Our faculty is comprised of researchers from nine Departments and three Schools at the University of Virginia. They share common research interests and facilities including high-end structural biology and microscopy equipment to achieve a deeper understanding of how cells and in particular cell membranes function.

UVA Center for Membrane and Cell Physiology researcher in his lab.

Meet the Director

Dr. Lukas K. Tamm directs the Center for Membrane and Cell Physiology. His research interests include studies on virus entry into cells by membrane fusion, neurotransmitter release at synapses by exocytosis of synaptic vesicles at nerve termini, and the study of the structures of bacterial outer membrane transporters by nuclear magnetic resonance.
Learn More

Membrane and Cell Physiology image.

Research Areas at the Center

Membrane and Cell Physiology faculty focus their research on the following areas: Membrane Transport; Membrane Fusion; Host-Pathogen Interactions; Signal Transduction; and Membrane Channels & Receptors.
Read about the research areas

UVA Center for Membrane and Cell Physiology researcher in lab looking through microscope

Methods and Resources at the Center

Faculty use the following methods and resources for research: Electron Microscopy; Magnetic Resonance Spectroscopy; Molecular Modeling and Computer Simulation; Optical Microscopy and Single Molecule Fluorescence; and X-ray Crystallography.
Current Resources

A Deeper Understanding

Four primary labs are associated with the Center for Membrane and Cell Physiology, each seeking a deeper understanding of cell physiology:

  • Ai Lab – Developing novel molecular probes to peer into cells and brains to understand their communications.
  • Kenworthy Lab – Examining the role of membrane microdomains such as lipid rafts and caveolae in health and disease and the role of intracellular protein dynamics and complex formation in autophagy.
  • Levental Lab – understanding the fundamental mechanisms by which membranes and dietary lipids regulate cell physiology.
  • Redemann Lab – Investigating the mechanisms and principles of spindle assembly and chromosome segregation.
  • Tamm Lab – Studying the structure and function of a variety of membrane proteins of clinical importance in their natural membrane environment.