Laboratory of Protein Engineering: Advancing Imaging, Therapeutics, and Diagnostics

The Ai lab specializes in protein engineering and employs interdisciplinary approaches, including biophysics, bioanalytical chemistry, chemical biology, synthetic biology, and optical imaging.

One of our main areas of focus is the development of molecular biosensors that provide insights into cellular and organismal signaling. We employ state-of-the-art techniques such as directed evolution, fluorescence imaging, bioluminescence imaging, synthetic chemistry, genetic screening, and mass spectrometry to unravel complex biological pathways related to redox biology, metabolism, and neuronal activity.

Furthermore, we explore the application of protein-based tools in live cells and rodent models to better understand pathophysiology and develop innovative therapies for conditions like diabetes, Alzheimer’s disease, and cancer. As an emerging direction, we are also working on the development of biosensors that can serve as self-wellness alert devices or diagnostics in resource-limited settings.

We recognize and respect that our work and learning take place on a campus initially constructed by enslaved African Americans on the land of the Monacan Native Americans.