Engineer Proteins to Image Bioactivity

My lab uses interdisciplinary approaches in biophysics, chemical biology, molecular engineering, and optical imaging to study and control complex biological systems, with a focus on developing novel molecular biosensors to peer into cells and organisms to understand signaling and communication. We use innovative technologies, such as directed evolution, fluorescence imaging, bioluminescence imaging, synthetic chemistry, genetic screening, and mass spectrometry, to dissect biological pathways related to redox biology, metabolism, and neuronal activity. Our immediate goal is to monitor biological signaling in real time with excellent spatial resolution and molecular precision in physiologically relevant environments. Our long-term goal is to apply these new tools in live cells and rodent models to understand and develop new therapies for diabetes and neurological disorders.