Research

Engineer Proteins to Image Bioactivity

My lab uses interdisciplinary approaches in biophysics, chemical biology, bioengineering, and electrophysiology to study and manipulate complex biological systems, with a focus on the development of novel molecular biosensors to peer into cells and organisms to understand their communications. We use a collection of technologies, such as protein engineering, fluorescence imaging, bioluminescence imaging, synthetic chemistry, and electrophysiology, to dissect biological pathways related to metabolism, redox signaling, and neurotransmission. Our immediate goal is to monitor biological signaling in real time with excellent spatial resolution and molecular precision in physiologically relevant environments. Our long-term goal is to apply these new probes to live cells and rodent models to understand communications relevant to diabetes, cognition and behavior, and neurological disorders.

Funding Sources