Protein Engineering for Bioactivity Imaging

Our lab develops novel molecular biosensors to peer into cells and organisms to understand biosignaling and communications. We use a collection of innovative techniques, such as protein engineering, fluorescence and bioluminescence imaging, synthetic chemistry, electrophysiology, and MRI/PET, to dissect signaling pathways related to metabolism, redox biology, insulin receptor signaling, and neurotransmission. Our immediate goal is to monitor biological signaling in real time with excellent spatial resolution and molecular precision in physiologically relevant environments. Our long-term goal is to apply these new probes to live cells and rodent models to understand communications relevant to diabetes, cognition and behavior, and neurological disorders.

Funding Sources