Research in Epigenetics at UVA focuses on the study of heritable changes in phenotype and gene function that are not caused by direct alterations in DNA sequence. DNA in eukaryotic cells is packaged into chromatin by histone proteins. DNA-driven cellular processes such as gene expression require alteration of chromatin structure to access this packaged DNA. Epigenetic changes, including chromatin remodeling, histone exchange, or chemical modification of histone proteins, affect access to chromatin DNA. Modifications to the chromatin through processes such as DNA methylation and histone acetylation are being increasingly appreciated as key determinants of cellular phenotype. Epigenetic chromatin modification is also influenced by environmental factors and can be stably transmitted across generations.
Improved understanding of epigenetic processes is producing exciting advances in cancer detection and treatment. For example, epigenetic profiles can improve cancer detection, and new anti-cancer drugs target the chromatin modifying machinery.
The UVA epigenetics research groups utilize model organisms, mammalian cells and human-derived samples in their studies. A variety of experimental approaches, including biochemistry, genetics, genome-wide analysis and bioinformatics, and behavioral studies are being applied to study epigenetic mechanisms and changes associated with human disease.
Auble, David T.
Molecular Mechanisms of Transcriptional Regulation
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Epigenetic and genetic mechanisms underlying metabolic disease
Systems Genetics Approaches to Understand Cardiometabolic Traits
Herpes Simplex Virus Infection of Neurons
Connelly, Jessica J.
Epigenetic mechanisms involved in complex human disease
Systems Immunology, Cancer Systems Biology, , Neonatal and Maternal Immunology
Cancer systems biology, Single-cell quantitative biology, Computational modeling
Felder, Robin A.
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
Acute Myeloid Leukemia: molecular and cellular biology events which mediate aberrant epigenetic and transcriptional mechanisms during disease establishment and progression
Goldfarb, Adam N.
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
Harris, Thurl E
Molecular mechanisms controlling insulin signaling and fat synthesis.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
Kuyumcu-Martinez, Muge N
RNA regulatory networks and RNA binding proteins during cardiovascular development and in cardiovascular disease
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Lynch, Wendy J.
Behavioral Pharmacology, Sex Differences, Animal Models of Addiction
Mayo, Marty W.
Transcriptional Regulation by NFKB
Miller, Clint L.
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
Owens, Gary K.
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Mechanisms of tissue/organ homeostasis and tumorigeensis
Pemberton, Lucy F.
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Rekosh, David M.
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Rich, Stephen S.
Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
computational biology & bioinformatics; high performance computing; epigenomics & chromatin; pediatric cancer; computational regulatory genomics; machine learning
Smith, Jeffrey S.
Transcriptional Silencing and Aging in Yeast
Stukenberg, P. Todd
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Regulation of cell-surface stability and intracellular trafficking of membrane proteins in epithelial cells
Trinh, Bon Q
Understanding Protein and RNA regulations of gene expression via chromatin structure in myeloid cell development and diseases
Genome instability in cancer and repeat expansion diseases
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Advanced machine learning; Theoretical and computational biophysic