Recent Publications
Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates
Mandal A, Shetty J, Tran CA, Olson WC, Mandal M, Ban B, Pires ES, Adair SJ, Bauer TW, Slingluff CL Jr, Herr JC. Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates. J Immunother Cancer. 2024 Mar 13;12(3):e008430. doi: 10.1136/jitc-2023-008430. PMID: 38485187; PMCID: PMC10941168.
38485187Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS. Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal. Nat Cell Biol. 2024 Feb;26(2):194-206. doi: 10.1038/s41556-023-01343-1. Epub 2024 Feb 8. PMID: 38332353.
38332353Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium
Dunaway LS, Luse MA, Nyshadham S, Bulut G, Alencar GF, Chavkin NW, Cortese-Krott M, Hirschi KK, Isakson BE. Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium. Physiol Genomics. 2024 Feb 1;56(2):113-127. doi: 10.1152/physiolgenomics.00109.2023. Epub 2023 Nov 20. PMID: 37982169.
37982169Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation. 2024 Mar 19;149(12):944-962. doi: 10.1161/CIRCULATIONAHA.122.062952. Epub 2023 Dec 21. PMID: 38126211; PMCID: PMC10954087.
38126211Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages
Wilcox NS, Yarovinsky TO, Pandya P, Ramgolam VS, Moro A, Wu Y, Nicoli S, Hirschi KK, Bender JR. Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. iScience. 2023 Sep 21;26(12):107985. doi: 10.1016/j.isci.2023.107985. PMID: 38047075; PMCID: PMC10690575.
38047075Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans
Chavkin NW, Vippa T, Jung C, McDonnell S, Hirschi KK, Gokce N, Walsh K. Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans. Front Cardiovasc Med. 2023 Sep 19;10:1264479. doi: 10.3389/fcvm.2023.1264479. PMID: 37795485; PMCID: PMC10546194.
37795485Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction
Cochran JD, Yura Y, Thel MC, Doviak H, Polizio AH, Arai Y, Arai Y, Horitani K, Park E, Chavkin NW, Kour A, Sano S, Mahajan N, Evans M, Huba M, Naya NM, Sun H, Ban YH, Hirschi KK, Toldo S, Abbate A, Druley TE, Ruberg FL, Maurer MS, Ezekowitz JA, Dyck JRB, Walsh K. Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction. Circulation. 2023 Oct 10;148(15):1165-1178. doi: 10.1161/CIRCULATIONAHA.123.064170. Epub 2023 Sep 8. PMID: 37681311; PMCID: PMC10575571.
37681311Right place, right time – Spatial guidance of neuronal morphogenesis by septin GTPases
Radler MR, Spiliotis ET. Right place, right time - Spatial guidance of neuronal morphogenesis by septin GTPases. Curr Opin Neurobiol. 2022 Aug;75:102557. doi: 10.1016/j.conb.2022.102557. Epub 2022 May 21. PMID: 35609489; PMCID: PMC9968515.
35609489MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis
Wu Y, Paila U, Genet G, Hirschi KK. MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis. Dev Cell. 2023 Jun 6:S1534-5807(23)00240-X. doi: 10.1016/j.devcel.2023.05.007. Epub ahead of print. PMID: 37295435.
37295435Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice
Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V. Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Cell. 2023 May 25;186(11):2345-2360.e16. doi: 10.1016/j.cell.2023.04.017. Epub 2023 May 10. PMID: 37167971; PMCID: PMC10225355.
37167971